Michele FIORE

Dr Michele FIORE (MCF)

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04 72 44 80 80

2014 - Present : Assistant Professor (MCF), Université Claude Bernard Lyon 1
2011 - 2014 : Postdoctoral studies, Université Grenoble Alpes (Prof Olivier Renaudet)
2009 - 2011 : Junior Scientist, Sienabiotech Spa (Italy)
2008 - 2009 : Postdoctoral studies, University of Ferrara (Prof Alessandro Dondoni / Prof Alberto Marra)
2003 - 2007 : PhD in Agrobiology and Agrochemistry, University of Naples (Prof. Antonio Evidente)

32. Fayolle, D.; Altamura, E.; D’Onofrio, A.; Madanamothoo, W.; Fenet, B.; Mavelli, F.; Buchet, R.; Stano, P.; Fiore, F.; Strazewski, P. 
Crude phosphorylation mixtures containing racemic lipid amphiphiles self-assemble to give stable primitive compartments.
Sci. Rep. DOI:10.1038/s41598-017-18053-y


31. Glass Microsphere-Supported Giant Vesicles as Tools for Observation of Self-reproduction of Lipid Boundaries
Fiore, M.; Maniti, O.; Girard-Egrot, A.; Monnard, P.-A.; Strazewski P.
Angew. Chem. Int. Ed. DOI:10.1002/anie.201710708
Angew. Chem. DOI:10.1002/ange.201710708


30. Chemo-bacterial synthesis of a sialyl-Tn cyclopeptide vaccine Candidate. E. Richard, C. Pifferi, M. Fiore, E. Samain, A. Le Gouëllec, S. Fort, O. Renaudet and B. Priem, ChemBioChem., 2017, DOI: 10.1002/cbic.201700240


29. Aminooxylated Carbohydrates: Synthesis and Applications. C. Pifferi, G. C. Daskhan, M. Fiore, T. C. Shiao, R. Roy, O. Renaudet, Chem. Rev. 2017, 117, 9839−9873


28. Giant vesicles from rehydrated crude mixtures containing unexpected mixtures of amphiphiles formed under plausibly prebiotic conditions.
Fiore, M.; Madanamoothoo, W.; Berlioz-Barbier, A.; Maniti, O.; Girard-Egrot, A.; Buchet, R.; Strazewski P.
Org. Biomol. Chem. 2017, 15, 4231-4240 DOI:10.1039/c7ob00708f


27. Bringing Prebiotic Nucleosides and Nucleotides Down to Earth.
Zur präbiotischen Synthese von Nukleosiden und Nukleotiden
M Fiore, P Strazewski
Angew. Chem. Int. Ed. 2016, 55, 13930-13933
Angew. Chem. 2016, 128, 14134-14137


26. Prebiotic Lipidic Amphiphiles and Condensing Agents on the Early Earth
M Fiore* and P Strazewski*
Life, 2016, 6, 17; doi:10.3390/life6020017


24. Role of a Preorganized Scaffold Presenting Four Residues of a GM3 Lactone Mimetic on Melanoma Progression
Barbara Richichi, Giuseppina Comito, Olivier Renaudet, Michele Fiore,A. Marra, B. Stecca, L. Pasquato, P. Chiarugi, and C. Nativi
ACS Med. Chem. Lett.,2016,7, 28–33


23. Divergent and convergent synthesis of GalNAc-conjugated dendrimers using dual orthogonal ligations
Baptiste Thomas, Carlo Pifferi, Gour Chand Daskhan, Michele Fiore, Nathalie Berthet and Olivier Renaudet
Org. Biomol. Chem., 2015, 13, 11529-11538


22. Multivalent glycocyclopeptides: toward nano-sized glycostructures
Gour Chand Daskhan, Nathalie Berthet, Baptiste Thomas, Michele Fiore and Olivier Renaudet
Carbohyd. Res., 2015, 405, 13–22

21. Oligomers for molecular recognition made by AROP of disubstituted cyclopropane-1,1-dicarboxylates,
S. Peyrat, M. Fiore, N. Illy, S. Boileau, V. Wintgens, N. Berthet, O. Renaudet, J. Penelle and V. Barbier,
Proceeding MACRO 2014: Recent development in polymer synthesis, 284-287


20. Clustered Tn-Antigen Mimetics-Based Cancer Therapeutic Vaccine Induces Strong Antibody-Mediated Protective Immunity
Barbara Richichi, Baptiste Thomas, Michele Fiore, Rosa Bosco, Khaled Kabbara, Kenneth Cao, Huma Qureshi, Cristina Nativi, Olivier Renaudet and Lbachir BenMohamed,
Angew. Chem. Int. Ed., 2014, 53, 11917–11920


19. A multi-ligation strategy for the synthesis of heterofunctionalized glycosylated scaffolds
Baptiste Thomas, Michele Fiore, Gour Chand Daskhan and Olivier Reanudet
Chem. Commun. 2014, 50, 8989-8992


18. New glycopolimers as multivalent system for lectin recognition
Michele Fiore,
Nathalie Berthet, Olivier Renaudet and Valessa Barbier
MedChem Comm., 2014, 5, 1202-1207


17. Orthogonal dual thiol-chloroacetyl and thiol-ene couplings for the sequential one-pot assembly of heteroglycoclusters
Michele Fiore,
Gour Chand Daskhan, Baptiste Thomas and Olivier Renaudet
Beilstein J. Org. Chem., 2014, 10, 1557-1563.


16. Access to topological biomolecular platform using a simple protocol based on oxime ligation
Karen Kŕenek, Radek Gazak, Miroslav Sulc, Gour Chand Daskhan, Julian Garcia, Michele Fiore, Pascal Dumy, Vladimir Kŕen and Olivier Renaudet
Carbohyd. Res., 2014, 393, 9-14


15. Reevaluation of binding properties of recombinant lymphocyte receptors NKR-P1A and CD69 to chemically synthesized glycans and peptides.
Daniel Rozbeský, Jana Krejzová, Karel Krenek, Jan Prchal, Richard Hrabal, Milan Kozísek,
Lenka Weignerová, Michele Fiore, Pascal Dumy, Olivier Renaudet, Vladimir Kren
Int. J. Mol. Sci., 2014, 14, 1271-1283


14. Tetravalent GlcNAc Glycoclusters : influence of the Linker for the Weat Germ Agglutinin Interaction.
Michele Fiore,
Nathalie Berthet, Pascal Dumy, Alberto Marra, Alessandro Dondoni, Emilie Gillion, Anne Imberty, Olivier Renaudet.
Org. Biomol. Chem., 2013, 11, 7113-7122


13. Facile Synthesis of multi-antigenic platform as vaccine candidates against cancers
Michele Fiore,
Baptiste Thomas, Vincent Dulery, Pascal Dumy, Olivier Renaudet
New. J. Chem., 2013, 37, 286-289


12. Synthesis of heteroglycoclusters by using orthogonal chemoselective ligations
Baptiste Thomas, Michele Fiore, Isabelle Bossu, Pascal Dumy and Olivier Renaudet
Beilstein J. Org. Chem., 2012, 8, 421–427


11. Effects of the aglycone of ascaulitoxin on amino acid metabolism in Lemna paucicostata
Stephen O. Duke, Antonio Evidente, Michele Fiore, Agnes M. Rimando, Franck E. Dayan,
Maurizio Vurro, Nicole Christiansen, Ralf Looser, Johannes Hutzler, Klaus Grossmann
Pest. Biochem. Physiol., 2011, 100, 41–50


10. Analysis of phytotoxic fungal toxins from Ascochyta caulina liquid culture
Agnes M, Rimando, Michele Fiore, Antonio Evidente
Abstr. Pap. Am. Chem. S., 2010, 239, 96-99


09. A new GC-MS method for the analysis of ascaulitoxin, its aglycone and 4-aminoproline from culture filtrates of Ascochita caulina
Michele Fiore
, Agnes Rimando, Anna Andolfi and Antonio Evidente
Anal. Methods, 2010, 2, 159 - 163


08. Synthesis of S-glycosyl amino acids and S-glycosilpeptides via photoinduced click thiol-ene coupling
Michele Fiore
, Salvatore Pacifico, Mauro Lo Conte, Alberto Marra and Alessandro Dondoni
Tetrahedron Lett., 2011, 52 , 444–447


07. Photoinduced Thiol Ene Coupling as a Click Ligation tool for Thiodisaccarides Synthesis
Michele Fiore
, Alberto Marra and Alessandro Dondoni
J. Org. Chem., 2009, 74, 4422 – 4425


06. Single and Dual glycoside clustering around calix[4]arene scaffolds via click thiol ene and azide-alkyne cycloaddition
Michele Fiore,
Angela Chambery, Alberto Marra and Alessandro Dondoni.
Org. Biomol. Chem., 2009, 7, 3910 - 3913


05. Diplofuranones A and B, two Further New 4-Monosubstituted 2(3H)-dihydrofuranones Produced by Diplodia corticola, a Fungus Pathogen of Cork Oak
Antonio Evidente, Anna Andolfi, Michele Fiore, Emanuela Spanu, Antonio Franceschini, and Lucia Maddau
Archiv. O. C., 2007, 7, 318 – 320


04. Diplobifuranylones A and B, 5’-Monosubstituted Tetrahydro-2H-bifuranyl-5-ones Produced by Diplodia corticola, a Fungus Pathogen of Cork Oak
Antonio Evidente, Anna Andolfi, Michele Fiore, Emanuela Spanu, Lucia Maddau, Antonio Franceschini, Francesco Marras, and Andrea Motta
J. Nat. Prod., 2006, 69, 671-674


03. Chemical and biological characterisation of sapinopyridione, a phytotoxic 3,3,6-trisubstituted-2,4-pyridione produced by Sphaeropsis sapinea, a toxigenic pathogen of native and exotic conifers, and its derivatives
Antonio Evidente, Michele Fiore, Giovanni Bruno,Lorenzo Sparapano, Andrea Motta
Phytochemistry, 2006, 67, 1019–1028


02. Occurence, isolation and biological activity of phytotoxic metabolites produced in vitro by Spaeropsis sapinea, pathogenic fungus of Pinus radiata
Annalisa Cabras, Maria A. Mannoni, Salvatorica Serra, Anna Andolfi, Michele Fiore and Antonio Evidente
Eur. J. Plant Path., 2006, 115, 187-193


01. Stimulation of Orobanche ramosa seed germination by fusicoccin derivatives: A structure–activity relationship study
Antonio Evidente, Anna Andolfi, Michele Fiore, Angela Boari, Maurizio Vurro
Phytochemistry, 2006, 67, 19–26


Book Chapters


Protecting groups for the primary position of carbohydrates
Marion Donnier Marechal, Sebastian Vidal and Michele Fiore*


Carbohydrates Chemistry: State-of-the-art and challenges for drug development (2014)
Chapter 5
: Vaccines against cancer
Michele Fiore
, Baptiste Thomas, Gour Chan Daskhan, Olivier Renaudet,
Imperial College Press, London, Editor Prof. L. Cipolla, University of Milan, Italy ISBN: 9781783267194


Biomaterials for cancer therapeutics In Woodhead Publishing (2013)
Chapter 4: Chemical synthesis of carbohydrate-based vaccines against cancers
Michele Fiore
, Baptiste Thomas, Pascal Dumy, Olivier Renaudet
DOI : 10.1533/ 9780857098924.2.57