Dr Michele FIORE (MCF)
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04 72 44 80 80
2019 - Present : Associate Professor (MCF HDR), Université Claude Bernard Lyon 1
2019 : Habilitation à Diriger les Recherches (HDR), Université Claude Bernard Lyon 1
2014 - 2019 : Assistant Professor (MCF), Université Claude Bernard Lyon 1
2011 - 2014 : Postdoctoral studies, Université Grenoble Alpes (Prof Olivier Renaudet)
2009 - 2011 : Junior Scientist, Sienabiotech Spa (Italy)
2008 - 2009 : Postdoctoral studies, University of Ferrara (Prof Alessandro Dondoni / Prof Alberto Marra)
2003 - 2007 : PhD in Agrobiology and Agrochemistry, University of Naples (Prof. Antonio Evidente)
Editorial contribution:
Guest Editor for the Special Issue of LIFE (ISSN 2075-1729) in the series Origin of Life:
Special Issue "The Origin and Early Evolution of Life: Prebiotic Systems Chemistry Perspective"
https://www.mdpi.com/journal/life/special_issues/Prebiotic_Systems_Chemistry_Biomolecules
Editor of the Book : Prebiotic Chemistry and Origin of Life Royal Chemical Society
Articles
44. Chromatophores Efficiently Promote Light-Driven ATP Synthesis and DNA 3 Transcription Inside Hybrid Multi-Compartment Artificial Cells.
E. Altamura, P. Albanese, R. Marotta, F. Milano, M. Fiore, M. Trotta, P. Stano and F. Mavelli
bioRxiv, doi: https://doi.org/10.1101/2020.02.05.933846
43. Chemical Analysis of Lipid Boundaries after Consecutive Growth and Division of Supported Giant Vesicles
A. Lopez, D. Fayolle, M. Fiore*, P. Strazewski
iScience, 2020, 23, 101677; https://doi.org/10.1016/j.isci.2020.101677
42. How lipids symmetry breaking occurred in common cell ancestors?
M. Fiore,* R. Buchet,
Symmetry 2020, 12, 1488; doi:10.3390/sym12091488
41. Racemic phospholipids for origin of life studies
E. Altamura, A. Comte, A. D’Onofrio, C. Roussillon, D. Fayolle, R. Buchet, F. Mavelli, P. Stano, M. Fiore,* P. Strazewski
Symmetry 2020, 12, 1108; doi:10.3390/sym12071108
40. The Origin and Early Evolution of Life: Prebiotic Chemistry.
M. Fiore
Life, 2019, 9, 73; doi:10.3390/life9030073
39. Investigating prebiotic protocells for a comprehensive understanding of the origins of life: a prebiotic systems chemistry perspective.
A. Lopez & M. Fiore*
Life, 2019, 9, 49; doi:10.3390/life9020049
37. Towards the preparation of synthetic outer membrane vesicle models with micromolar affinity to wheat germ agglutinin using a dialkyl thioglycoside.
D. Fayolle, B. Doumèche, N. Berthet, O. Renaudet, P. Strazewski and M. Fiore*
Beilstein J. Org. Chem. 2019, 15, 937–946. doi:10.3762/bjoc.15.90
36. Identification of a new natural gastric lipase inhibitor from star anise
J. Kamoun, R. Rahiern, M. Sellami, I. Koubaa, P. Mansuelle, R. Lebrun, A. Berlioz-Barbier, M. Fiore, K. Alvarez, A. Abousalham, F. Carrière, A. Aloulou,
Food Funct, 2019, 10, 469-478
35. The synthesis of mono-alkyl phosphates and their derivatives: an overview of their nature, preparation and use, including synthesis under plausible prebiotic conditions.
M. Fiore*,
Org. Biomol. Chem., 2018, 16, 3068–3086
34. Rapid purification of giant lipid vesicles by microfiltration.
D. Fayolle, M. Fiore, P. Stano and P.Strazewski;
PLoS ONE, 2018, 13: e0192975, DOI:10.1371/journal.pone.0192975
33. Glass Microsphere-Supported Giant Vesicles as Tools for Observation of Self-reproduction of Lipid Boundaries;
M. Fiore*, O. Maniti, A. Girard-Egrot, P-A Monnard and P. Strazewski*
Angew. Chem. Int. Ed., 2018, 57, 282–286;
32. Multivalent Glycomimetics with Affinity and Selectivity toward Fucose-Binding Receptors from Emerging Pathogens
D. Goyard, V. Baldoneschi, A. Varrot, M. Fiore, A. Imberty, B. Richichi, O. Renaudet, and C. Nativi
Bioconjugate Chem. 2018, 29, 83−88
31. Crude phosphorylation mixtures containing racemic lipid amphiphiles self-assemble to give stable primitive compartments; D. Fayolle, E. Altamura, A. D’Onofrio, W. J. Madanamothoo, B. Fenet, F. Mavelli, R. Buchet, P. Stano*, M. Fiore* and P.Strazewski*
Sci. Rep., 2017, 7, 18106;
30. Giant vesicles from rehydrated crude phosphorylation mixtures containing mono-alkyl phosphoethanolamine and its analogues;
M. Fiore*, W. Madanamoothoo, A. Berlioz-Barbier, O. Manniti, A. Girard-Egrot, R. Buchet, P. Strazewski*;
Org. Biomol. Chem., 2017, 15, 4231–4238.
29. Bringing down to earth prebiotic nucleosides and nucleotides
M. Fiore, P. Strazewski*;
Angew. Chem. Int. Ed., 2016, 55, 13930–13933.
28. Prebiotic lipidic amphiphiles and condensing agents on the early Earth
M. Fiore*, P. Strazewski*
Life, 2016, 6, 17.
27. Immunological characterization of a rigid α-Tn mimetic on murine iNKT and human NK cells.
S. Fallarini, A. Brittoli, M. Fiore, G. Lombardi, O. Renaudet, B. Richichi, C. Nativi,
Glycoconj. J., 2017, 34, 553–562.
26. Chemo-bacterial synthesis of a sialyl-Tn cyclopeptide vaccine Candidate.
E. Richard, C. Pifferi, M. Fiore, E. Samain, A. Le Gouëllec, S. Fort, O. Renaudet, B. Priem,
ChemBioChem., 2017,18, 1730–1734.
25. Aminooxiylated Carbohydrates: Synthesis and Applications.
C. Pifferi, G. C. Daskhan, M. Fiore, T. C. Shiao, R. Roy, O. Renaudet,
Chem. Rev. 2017, 117, 9839−9873.
24. Role of a preorganized scaffold presenting four residues of a GM3 lactone mimetic on melanoma progression
B. Richichi, G. Comito, O. Renaudet, M. Fiore, A. Marra, B. Stecca, L. Pasquato, P. Chiarugi, C. Nativi
ACS Med. Chem. Lett., 2016, 7, 28–33.
23. Divergent and convergent synthesis of GalNAc-conjugated dendrimers using dual orthogonal ligations
B. Thomas, C. Pifferi, G. C. Daskhan,M. Fiore, N. Berthet, O. Renaudet
Org. Biomol. Chem., 2015, 13, 11529–11538.
22. Multivalent glycocyclopeptides: toward nano-sized glycostructures
G. C. Daskhan, N. Berthet, B. Thomas, M. Fiore, O. Renaudet
Carbohyd. Res., 2015, 405, 13–22.
21. Oligomers for molecular recognition made by AROP of disubstituted cyclopropane-1,1-dicarboxiylates
S. Peyrat, M. Fiore, N. Illy, S. Boileau, V. Wintgens, N. Berthet, O. Renaudet, J. Penelle, V. Barbier,
Proceeding MACRO 2014: Recent development in polymer synthesis, 284–286.
20. Clustered Tn-Antigen Mimetics-Based Cancer Therapeutic Vaccine Induces Strong Antibody-Mediated Protective Immunity
B. Richichi, B. Thomas, M. Fiore, R. Bosco, K. Kabbara, K. Cao, H. Qureshi, C. Nativi, O. Renaudet, L. Ben Mohamed, Angew. Chem. Int. Ed., 2014, 53, 11917–11920.
19. A multi-ligation strategy for the synthesis of heterofunctionalized glycosylated scaffolds
B. Thomas, M. Fiore, G. C. Daskhan, N. Spinelli, O. Renaudet
Chem. Commun., 2014, 50, 8989–8992.
18. New glycopolimers as multivalent system for lectin recognition
M. Fiore, N. Berthet, O. Renaudet, V. Barbier
MedChem Comm., 2014, 5, 1202–1207.
17. Orthogonal dual thiol-chloroacetyl and thiol-ene couplings for the sequential one-pot assembly of heteroglycoclusters
M.Fiore, G. C.Daskhan, B. Thomas, O. Renaudet
Beilstein J. Org. Chem., 2014, 10, 1557–1563.
16. Access to topological biomolecular platform using a simple protocol based on oxiime ligation
K. Křenek, R. Gazak, M. Sulc, G. C. Daskhan, J. Garcia, M. Fiore, P. Dumy, V. Křen, O. Renaudet
Carbohyd. Res., 2014, 393, 9–14.
15. Reevaluation of binding properties of recombinant lymphocyte receptors NKR-P1A and CD69 to chemically synthesized glycans and peptides.
D. Rozbeský, J. Krejzová, K. Křenek, J. Prchal, R. Hrabal, M. Kozísek, L. Weignerová, M. Fiore, P. Dumy, O. Renaudet, V. Křen
Int. J. Mol. Sci., 2014, 14, 1271–1283.
14. Tetravalent GlcNAc Glycoclusters: influence of the Linker for the Weat Germ Agglutinin Interaction.
M. Fiore, N. Berthet, P. Dumy, A. Marra, A. Dondoni, E. Gillion, A. Imberty, O. Renaudet
Org. Biomol. Chem., 2013, 11, 7113–7122.
13. Facile Synthesis of multi-antigenic platform as vaccine candidates against cancers
M. Fiore, B. Thomas, V. Dulery, P. Dumy, O. Renaudet
New. J. Chem., 2013, 37, 286–289.
12. Synthesis of heteroglycoclusters by using orthogonal chemoselective ligations
B. Thomas, M. Fiore, I. Bossu, P. Dumy, O. Renaudet
BeilsteinJ. Org. Chem., 2012, 8, 421–427.
11. Synthesis of S-glycosyl amino acids and S-glycosilpeptides via photoinduced click thiol-ene coupling
M. Fiore, S. Pacifico, M. Lo Conte, A. Marra, A. Dondoni
Tetrahedron Lett., 2011, 52 , 444–447.
10. Photoinduced Thiol Ene Coupling as a Click Ligation tool for Thiodisaccarides Synthesis
M. Fiore, A. Marra, A. Dondoni
J. Org. Chem., 2009, 74, 4422–4425.
09. Single and Dual glycoside clustering around calix[4]arene scaffolds via click thiol ene and azide-alkyne cycloaddition
M. Fiore, A. Chambery, A. Marra, A. Dondoni
Org. Biomol. Chem., 2009, 7, 3910–3913.
08. Effects of the aglycone of ascaulitoxin on amino acid metabolism in Lemna paucicostata
Stephen O. Duke, Antonio Evidente, Michele Fiore, Agnes M. Rimando, Franck E. Dayan, Maurizio Vurro, Nicole Christiansen, Ralf Looser, Johannes Hutzler, Klaus Grossmann
Pest. Biochem. Physiol., 2011, 100, 41–50.
07. Analysis of phytotoxiic fungal toxins from Ascochytacaulina liquid culture
Agnes M, Rimando, MicheleFiore, Antonio Evidente
Abstr. Pap. Am. Chem. S., 2010, 239, 96–99.
06. A new GC-MS method for the analysis of ascaulitoxin, its aglycone and 4-aminoproline from culture filtrates of Ascochitacaulina
Michele Fiore, Agnes Rimando, Anna Andolfi, Antonio Evidente
Anal. Methods, 2010, 2, 159–163.
05. Diplofuranones A and B, two Further New 4-Monosubstituted 2(3H)-dihydrofuranones Produced by Diplodiacorticola, a Fungus Pathogen of Cork Oak
Antonio Evidente, Anna Andolfi, Michele Fiore, Emanuela Spanu, Antonio Franceschini, Lucia Maddau Archiv. O. C., 2007, 7, 318–320.
04. Diplobifuranylones A and B, 5’-Monosubstituted Tetrahydro-2H-bifuranyl-5-ones Produced by Diplodiacorticola, a Fungus Pathogen of Cork Oak
Antonio Evidente, Anna Andolfi, Michele Fiore, Emanuela Spanu, Lucia Maddau, Antonio Franceschini, Francesco Marras, Andrea Motta
J. Nat. Prod., 2006, 69, 671–674.
03. Chemical and biological characterisation of sapinopyridione, a phytotoxic 3,3,6-trisubstituted-2,4-pyridione produced by Sphaeropsis sapinea, a toxigenic pathogen of native and exotic conifers, and its derivatives
Antonio Evidente, Michele Fiore, Giovanni Bruno,Lorenzo Sparapano, Andrea Motta
Phytochemistry, 2006, 67, 1019–1028.
02. Occurence, isolation and biological activity of phytotoxic metabolites produced in vitro by Spaeropsissapinea, pathogenic fungus of Pinusradiata
Annalisa Cabras, Maria A. Mannoni, Salvatorica Serra, Anna Andolfi, Michele Fiore, Antonio Evidente
Eur. J. Plant Path., 2006, 115, 187–193.
01. Stimulation of Orobancheramosa seed germination by fusicoccin derivatives: A structure–activity relationship study
Antonio Evidente, Anna Andolfi, Michele Fiore, Angela Boari, Maurizio Vurro
Phytochemistry, 2006, 67, 19–26.
Book editor
The Origin and Early Evolution of Life: Prebiotic Chemistry (2019)
M. Fiore, Editor. MDPI, St. Alban-Anlage 66
4052 Basel, Switzerland
ISBN 978-3-03921-606-2 (Pbk); ISBN 978-3-03921-607-9 (PDF)
Book chapters
Following the Growth and Division of Lipid Boundaries by Using
Glass Microsphere-Supported Protocells (2020)
A. Lopez, C. Chieffo, M. Fiore*
In: Book Series: Lecture Notes in Bioengineering
S. Piotto, S. Concilio, L. Sessa, F. Rossi, Editors
Publisher: Springer International Publishing
Print ISBN: 978-3-030-47704-2
Protecting groups for the primary position of carbohydrates (2018)
M. Donnier-Marechal, S. Vidal, M. Fiore*
In “Protecting Groups - Strategies and Applications in Carbohydrate Chemistry”
Wiley-VCH, Editor S. Vidal, Université de Lyon, Claude Bernard Lyon 1,
ISBN: 978-3-527-34010-1
Vaccines against cancer (2014)
M. Fiore, B. Thomas, G.C. Daskhan, O. Renaudet,
In Carbohydrates Chemistry: State-of-the-art and challenges for drug development
Imperial College Press, London, Editor Prof. L. Cipolla University of Milan, Italy
ISBN: 9781783267194
Chemical synthesis of carbohydrate-based vaccines against cancer (2013)
M. Fiore, B. Thomas, P. Dumy, O. Renaudet
In Biomaterials for cancer therapeutics, Woodhead Publishing (2013)
DOI : 10.1533/ 9780857098924.2.57; ISBN: 9780857096647