Dr Michele FIORE (MCF)
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04 72 44 80 80
2019 - Present : Associate Professor (MCF HDR), Université Claude Bernard Lyon 1
2019 : Habilitation à Diriger les Recherches (HDR), Université Claude Bernard Lyon 1
2014 - 2019 : Assistant Professor (MCF), Université Claude Bernard Lyon 1
2011 - 2014 : Postdoctoral studies, Université Grenoble Alpes (Prof Olivier Renaudet)
2009 - 2011 : Junior Scientist, Sienabiotech Spa (Italy)
2008 - 2009 : Postdoctoral studies, University of Ferrara (Prof Alessandro Dondoni / Prof Alberto Marra)
2003 - 2007 : PhD in Agrobiology and Agrochemistry, University of Naples (Prof. Antonio Evidente)
Editorial contribution:
Guest Editor for the Special Issue of LIFE (ISSN 2075-1729): “The Origin and Early Evolution of Life: Prebiotic Chemistry” http://www.mdpi.com/journal/life/special_issues/Prebiotic_Chemistry
Member of the Editorial Board of Journal of Systems Biology & Proteome Research
Incoming publications
Phospholipids: nature, preparation and use. From organic synthesis, evolutionary to modern synthesis.
Michele Fiore* and René Buchet, Chem. Rev., 2018, Synopsis accepted.
Articles
37. Investigating prebiotic protocells for a comprehensive understanding of the origins of life: a prebiotic systems chemistry perspective.
A. Lopez & M. Fiore* Life, 2019, 9, 49; doi:10.3390/life9020049
36. Towards the preparation of synthetic outer membrane vesicle models with micromolar affinity to wheat germ agglutinin using a dialkyl thioglycoside
D. Fayolle, B. Doumèche, N. Berthet, O. Renaudet, P. Strazewski, M. Fiore*
Beilstein J. Org. Chem. 2019, 15, 937–946. doi:10.3762/bjoc.15.90
35. Identification of a new natural gastric lipase inhibitor from star anise
J. Kamoun, R. Rahiern, M. Sellami, I. Koubaa, P. Mansuelle, R. Lebrun, A. Berlioz-Barbier, M. Fiore, K. Alvarez, A. Abousalham, F. Carrière, A. Aloulou, Food Funct, 2019, 10, 469-478
34. The synthesis of mono-alkyl phosphates and their derivatives: an overview of their nature,
preparation and use, including synthesis under plausible prebiotic conditions.
M. Fiore*, Org. Biomol. Chem., 2018, 16, 3068–3086
33. Rapid purification of giant lipid vesicles by microfiltration.
D. Fayolle, M. Fiore, P. Stano and P.Strazewski;
PLoS ONE, 2018, 13: e0192975, DOI:10.1371/journal.pone.0192975
32. Glass Microsphere-Supported Giant Vesicles as Tools for Observation of Self-reproduction of Lipid Boundaries; M. Fiore*, O. Maniti, A. Girard-Egrot, P-A Monnard and P. Strazewski*
Angew. Chem. Int. Ed., 2018, 57, 282–286;
31. Crude phosphorylation mixitures containing racemic lipid amphiphiles self-assemble to give stable primitive compartments; D. Fayolle, E. Altamura, A. D’Onofrio, W. J. Madanamothoo, B. Fenet, F. Mavelli, R. Buchet, P. Stano*, M. Fiore* and P.Strazewski* Sci. Rep., 2017, 7, 18106;
30. Giant vesicles from rehydrated crude phosphorylation mixitures containing mono-alkyl phosphoethanolamine and its analogues;
M. Fiore*, W. Madanamoothoo, A. Berlioz-Barbier, O. Manniti, A. Girard-Egrot, R. Buchet, P. Strazewski*; Org. Biomol. Chem., 2017, 15, 4231–4238
29. Bringing down to earth prebiotic nucleosides and nucleotides
M. Fiore, P. Strazewski*; Angew. Chem. Int. Ed., 2016, 55, 13930–13933
28. Prebiotic lipidicamphiphiles and condensing agents on the early Earth
M. Fiore*, P. Strazewski* Life, 2016, 6, 17.
27. Immunological characterization of a rigid α-Tn mimetic on murine iNKT and human NK cells.
S. Fallarini, A. Brittoli, M. Fiore, G. Lombardi, O. Renaudet, B. Richichi, C. Nativi,
Glycoconj. J., 2017, 34, 553–562
26. Chemo-bacterial synthesis of a sialyl-Tncyclopeptide vaccine Candidate.
E. Richard, C. Pifferi, M. Fiore, E. Samain, A. Le Gouëllec, S. Fort, O. Renaudet, B. Priem,
ChemBioChem., 2017,18, 1730–1734
25. Aminooxiylated Carbohydrates: Synthesis and Applications.
C. Pifferi, G. C. Daskhan, M. Fiore, T. C. Shiao, R. Roy, O. Renaudet,
Chem. Rev. 2017, 117, 9839−9873
24. Role of a preorganized scaffold presenting four residues of a GM3 lactone mimetic on melanoma progression
B. Richichi, G. Comito, O. Renaudet, M. Fiore, A. Marra, B. Stecca, L. Pasquato, P. Chiarugi, C. Nativi
ACS Med. Chem. Lett.2016, 7, 28–33
23. Divergent and convergent synthesis of GalNAc-conjugated dendrimers using dual orthogonal ligations
B. Thomas, C. Pifferi, G. C. Daskhan,M. Fiore, N. Berthet, O. Renaudet
Org. Biomol. Chem., 2015, 13, 11529–11538.
22. Multivalent glycocyclopeptides: toward nano-sized glycostructures
G. C. Daskhan, N. Berthet, B. Thomas, M. Fiore, O. Renaudet
Carbohyd. Res., 2015, 405, 13–22.
21. Oligomersfor molecular recognition made by AROP of disubstituted cyclopropane-1,1-dicarboxiylates
S. Peyrat, M. Fiore, N. Illy, S. Boileau, V. Wintgens, N. Berthet, O. Renaudet, J. Penelle, V. Barbier,
Proceeding MACRO 2014: Recent development in polymer synthesis, 284–286.
20. Clustered Tn-Antigen Mimetics-Based Cancer Therapeutic Vaccine Induces Strong Antibody-Mediated Protective Immunity
B. Richichi, B. Thomas, M. Fiore, R. Bosco, K. Kabbara, K. Cao, H. Qureshi, C. Nativi, O. Renaudet, L. Ben Mohamed, Angew. Chem. Int. Ed., 2014, 53, 11917–11920.
19. A multi-ligation strategy for the synthesis of hetero functionalized glycosylated scaffolds
B. Thomas, M. Fiore, G. C. Daskhan, N. Spinelli, O. Renaudet
Chem. Commun. 2014, 50, 8989–8992.
18. New glycopolimers as multivalent system for lectin recognition
M. Fiore, N. Berthet, O. Renaudet, V. Barbier
MedChem Comm., 2014, 5, 1202–1207.
17. Orthogonal dual thiol-chloroacetyl and thiol-ene couplings for the sequential one-pot assembly of heteroglycoclusters
M.Fiore, G. C.Daskhan, B. Thomas, O. Renaudet
Beilstein J. Org. Chem., 2014, 10, 1557–1563.
16. Access to topological biomolecular platform using a simple protocol based on oxime ligation
K. Křenek, R. Gazak, M. Sulc, G. C. Daskhan, J. Garcia, M. Fiore, P. Dumy, V. Křen, O. Renaudet
Carbohyd. Res., 2014, 393, 9–14
15. Reevaluation of binding properties of recombinant lymphocyte receptors NKR-P1A and CD69 to chemically synthesized glycans and peptides.
D. Rozbeský, J. Krejzová, K. Křenek, J. Prchal, R. Hrabal, M. Kozísek, L. Weignerová, M. Fiore, P. Dumy, O. Renaudet, V. Křen
Int. J. Mol. Sci., 2014, 14, 1271–1283
14. Tetravalent GlcNAcGlycoclusters: influence of the Linker for the Weat Germ Agglutinin Interaction.
M. Fiore, N. Berthet, P. Dumy, A. Marra, A. Dondoni, E. Gillion, A. Imberty, O. Renaudet
Org. Biomol. Chem., 2013, 11, 7113–7122
13. Facile Synthesis of multi-antigenic platform as vaccine candidates against cancers
M. Fiore, B. Thomas, V. Dulery, P. Dumy, O. Renaudet
New. J. Chem., 2013, 37, 286–289
12. Synthesis of heteroglycoclusters by using orthogonal chemoselective ligations
B. Thomas, M. Fiore, I. Bossu, P. Dumy, O. Renaudet
BeilsteinJ. Org. Chem., 2012, 8, 421–427
I.9.2.3. Articles écrits pendant le stage postdoctoral au sein du laboratoire de chimie à Ferrare (Equipe Prof. Alessandro Dondoni)
11. Synthesis of S-glycosyl amino acids and S-glycosilpeptides via photoinduced click thiol-ene coupling
M. Fiore, S. Pacifico, M. Lo Conte, A. Marra, A. Dondoni
Tetrahedron Lett., 2011, 52 , 444–447
10. Photoinduced Thiol Ene Coupling as a Click Ligation tool for Thiodisaccarides Synthesis
M. Fiore, A. Marra, A. Dondoni
J. Org. Chem., 2009, 74, 4422–4425
09. Single and Dual glycoside clustering around calix[4]arene scaffolds via click thiol ene and azide-alkyne cycloaddition
M. Fiore, A. Chambery, A. Marra, A. Dondoni
Org. Biomol. Chem., 2009, 7, 3910–3913
08. Effects of the aglycone of ascaulitoxin on amino acid metabolism in Lemna paucicostata
Stephen O. Duke, Antonio Evidente, Michele Fiore, Agnes M. Rimando, Franck E. Dayan, Maurizio Vurro, Nicole Christiansen, Ralf Looser, Johannes Hutzler, Klaus Grossmann
Pest. Biochem. Physiol., 2011, 100, 41–50
07. Analysis of phytotoxic fungal toxins from Ascochyta caulina liquid culture
Agnes M, Rimando, MicheleFiore, Antonio Evidente
Abstr. Pap. Am. Chem. S., 2010, 239, 96–99
06. A new GC-MS method for the analysis of ascaulitoxin, its aglycone and 4-aminoproline from culture filtrates of Ascochita caulina
Michele Fiore, Agnes Rimando, Anna Andolfi, Antonio Evidente
Anal. Methods, 2010, 2, 159–163
05. Diplofuranones A and B, two Further New 4-Monosubstituted 2(3H)-dihydrofuranones Produced by Diplodi acorticola, a Fungus Pathogen of Cork Oak
Antonio Evidente, Anna Andolfi, Michele Fiore, Emanuela Spanu, Antonio Franceschini, Lucia Maddau
Archiv. O. C., 2007, 7, 318–320
04. Diplobifuranylones A and B, 5’-Monosubstituted Tetrahydro-2H-bifuranyl-5-ones Produced by Diplodia corticola, a Fungus Pathogen of Cork Oak
Antonio Evidente, Anna Andolfi, Michele Fiore, Emanuela Spanu, Lucia Maddau, Antonio Franceschini, Francesco Marras, Andrea Motta
J. Nat. Prod., 2006, 69, 671–674
03. Chemical and biological characterisation of sapinopyridione, a phytotoxic 3,3,6-trisubstituted-2,4-pyridione produced by Sphaeropsis sapinea, a toxigenic pathogen of native and exiotic conifers, and its derivatives
Antonio Evidente, Michele Fiore, Giovanni Bruno,Lorenzo Sparapano, Andrea Motta
Phytochemistry, 2006, 67, 1019–1028
02. Occurence, isolation and biological activity of phytotoxic metabolites produced in vitro by Spaeropsis sapinea, pathogenic fungus of Pinus radiata
Annalisa Cabras, Maria A. Mannoni, Salvatorica Serra, Anna Andolfi, Michele Fiore, Antonio Evidente
Eur. J. Plant Path., 2006, 115, 187–193
01. Stimulation of Orobanche ramosa seed germination by fusicoccin derivatives: A structure–activity relationship study
Antonio Evidente, Anna Andolfi, Michele Fiore, Angela Boari, Maurizio Vurro
Phytochemistry, 2006, 67, 19–26