Dr Michele FIORE

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Michele FIORE

Dr Michele FIORE (MCF)

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04 72 44 80 80

2014 - Present : Assistant Professor (MCF), Université Claude Bernard Lyon 1
2011 - 2014 : Postdoctoral studies, Université Grenoble Alpes (Prof Olivier Renaudet)
2009 - 2011 : Junior Scientist, Sienabiotech Spa (Italy)
2008 - 2009 : Postdoctoral studies, University of Ferrara (Prof Alessandro Dondoni / Prof Alberto Marra)
2003 - 2007 : PhD in Agrobiology and Agrochemistry, University of Naples (Prof. Antonio Evidente)

Editorial contribution:

 

Guest Editor for the Special Issue of LIFE (ISSN 2075-1729): “The Origin and Early Evolution of Life: Prebiotic Chemistry” http://www.mdpi.com/journal/life/special_issues/Prebiotic_Chemistry

 

Member of the Editorial Board of Journal of Systems Biology & Proteome Research

 

Incoming publications

 

Phospholipids: nature, preparation and use. From organic synthesis, evolutionary to modern synthesis.

Michele Fiore* and René Buchet, Chem. Rev., 2018, Synopsis accepted.

 

Articles

  1. Multivalent Glycomimetics with Affinity and Selectivity toward Fucose-Binding Receptors from Emerging Pathogens

David Goyard, Veronica Baldoneschi, Annabelle Varrot, Michele Fiore, Anne Imberty,*,

Barbara Richichi, Olivier Renaudet and Cristina Nativi

Bioconjugate Chem., 2018, 29, 83–88; DOI: 10.1021/acs.bioconjchem.7b00616

 

  1. Glass Microsphere-Supported Giant Vesicles as Tools for Observation of Self-reproduction of Lipid Boundaries

Michele Fiore*, Ofelia Maniti, Agnes Girard-Egrot, Pierre-Alain Monnard, Peter Strazewski

Angew. Chem. Int. Ed. 2018, 57, 282-286; DOI:10.1002/anie.201710708

Angew. Chem. DOI:10.1002/ange.201710708

 

  1. Crude phosphorylation mixtures containing racemic lipid amphiphiles self-assemble to give stable primitive compartments.

Dimitri Fayolle, Emiliano Altamura, Alice D’Onofrio, Warren J. Madanamothoo, Bernard Fenet, Fabio Mavelli, René Buchet, Pasquale Stano*, Michele Fiore* and Peter Strazewski*

Sci. Rep. 2017, 7, 18106; DOI:10.1038/s41598-017-18053-y

 

  1. Immunological characterization of a rigid α-Tn mimetic on murine iNKT and human NK cells

Silvia Fallarini, Alvaro Brittoli, Michele Fiore, Grazia Lombardi, Olivier Renaudet, Barbara Richichi and Cristina Nativi

Glycoconj J., 2017, 34, 553-562; DOI 10.1007/s10719-017-9775-6

 

  1. Chemo-bacterial synthesis of a sialyl-Tn cyclopeptide vaccine Candidate.

Emilie Richard, Carlo Pifferi, Michele Fiore, E. Samain, A. Le Gouëllec, S. Fort, Olivier Renaudet and Bernard Priem, ChemBioChem., 2017, 18, 1730 – 1734; DOI: 10.1002/cbic.201700240

 

  1. Aminooxylated Carbohydrates: Synthesis and Applications.

Carlo Pifferi, Gour Chand Daskhan, Michele Fiore, T. C. Shiao, René Roy and Olivier Renaudet, Chem. Rev. 2017, 117, 9839−9873

 

  1. Giant vesicles from rehydrated crude mixtures containing unexpected mixtures of amphiphiles formed under plausibly prebiotic conditions.

Michele Fiore*, Warren Madanamoothoo, Alexandra Berlioz-Barbier, Ofelia Maniti, Agnes Girard-Egrot, René Buchet and Peter Strazewski*

Org. Biomol. Chem. 2017, 15, 4231-4240; DOI:10.1039/c7ob00708f

 

  1. Bringing Prebiotic Nucleosides and Nucleotides Down to Earth.

Zur präbiotischen Synthese von Nukleosiden und Nukleotiden

Michele Fiore and Peter Strazewski

Angew. Chem. Int. Ed. 2016, 55, 13930-13933; DOI:10.1002/anie.201606232

Angew. Chem. 2016, 128, 14134-14137; DOI:10.1002/ange.201606232

 

  1. Prebiotic Lipidic Amphiphiles and Condensing Agents on the Early Earth

Michele Fiore* and Peter Strazewski*

Life, 2016, 6, 17; DOI:10.3390/life6020017

 

  1. The Dual Role of A Pre-organized Scaffold Presenting Four Residues of a GM-3 Lactone Mimetic on Melanoma Modulation.

Barbara Richichi, Giuseppina Comito, Olivier Renaudet, Michele Fiore, Alberto Marra, Barbara Stecca,

Lucia Pasquato, Paola Chiarugi, and Cristina Nativi, ACS Med. Chem. Lett. 2016, 7, 28−33; DOI: 10.1021/acsmedchemlett.5b00283

 

  1. Divergent and convergent synthesis of GalNAc-conjugated dendrimers using dual orthogonal ligations

Baptiste Thomas,Carlo Pifferi, Gour Chand Daskhan, Michele Fiore, Nathalie Berthet, and Olivier. Renaudet, Org. Biomol. Chem., 2015, 13, 11529; DOI: 10.1039/c5ob01870f

 

  1. Multivalent glycocyclopeptides: toward nano-sized glycostructures

Gour Chand Daskhan, Nathalie Berthet, Baptiste Thomas, Michele Fiore and Olivier Renaudet

Carbohyd. Res., 2015, 405, 13–22

 

  1. Oligomers for molecular recognition made by AROP of disubstituted cyclopropane-1,1-dicarboxylates, S. Peyrat, Michele Fiore, N. Illy, S. Boileau, V. Wintgens, N. Berthet, O. Renaudet, J. Penelle and V. Barbier,Proceeding MACRO 2014: Recent development in polymer synthesis, 284-287

 

  1. Clustered Tn-Antigen Mimetics-Based Cancer Therapeutic Vaccine Induces Strong Antibody-Mediated Protective Immunity

Barbara Richichi, Baptiste Thomas, Michele Fiore,  Rosa Bosco, Khaled Kabbara, Kenneth Cao, Huma Qureshi, Cristina Nativi, Olivier Renaudet and Lbachir BenMohamed,

Angew. Chem. Int. Ed., 2014, 53, 11917–1192

 

  1. A multi-ligation strategy for the synthesis of heterofunctionalized glycosylated scaffolds

Baptiste Thomas, Michele Fiore, Gour Chand Daskhan and Olivier Reanudet

Chem. Commun. 2014, 50, 8989-8992

 

  1. New glycopolimers as multivalent system for lectin recognition

Michele Fiore, Nathalie Berthet, Olivier Renaudet and Valessa Barbier

MedChem Comm., 2014, 5, 1202-1207

 

  1. Orthogonal dual thiol-chloroacetyl and thiol-ene couplings for the sequential one-pot assembly of heteroglycoclusters

Michele Fiore, Gour Chand Daskhan, Baptiste Thomas and Olivier Renaudet 

Beilstein J. Org. Chem., 2014, 10, 1557-1563.

 

  1. Access to topological biomolecular platform using a simple protocol based on oxime ligation

Karen Kŕenek, Radek Gazak, Miroslav Sulc, Gour Chand Daskhan, Julian Garcia, Michele Fiore, Pascal Dumy, Vladimir Kŕen and Olivier Renaudet 

Carbohyd. Res., 2014, 393, 9-14

 

  1. Reevaluation of binding properties of recombinant lymphocyte receptors NKR-P1A and CD69 to chemically synthesized glycans and peptides.

Daniel Rozbeský, Jana Krejzová, Karel Krenek, Jan Prchal, Richard Hrabal, Milan Kozísek,

Lenka Weignerová, Michele Fiore, Pascal Dumy, Olivier Renaudet, Vladimir Kren

Int. J. Mol. Sci., 2014, 14, 1271-1283

 

  1. Tetravalent GlcNAc Glycoclusters : influence of the Linker for the Weat Germ Agglutinin Interaction.

Michele Fiore, Nathalie Berthet, Pascal Dumy, Alberto Marra, Alessandro Dondoni, Emilie Gillion, Anne Imberty, Olivier Renaudet. Org. Biomol. Chem., 2013, 11, 7113-7122

 

  1. Facile Synthesis of multi-antigenic platform as vaccine candidates against cancers                  Michele Fiore, Baptiste Thomas, Vincent Dulery, Pascal Dumy, Olivier Renaudet

New.  J. Chem., 2013, 37, 286-289

                                         

  1. Synthesis of heteroglycoclusters by using orthogonal chemoselective ligations

Baptiste Thomas, Michele Fiore, Isabelle Bossu, Pascal Dumy and Olivier Renaudet

Beilstein J. Org. Chem., 2012, 8, 421–427

 

  1. Effects of the aglycone of ascaulitoxin on amino acid metabolism in Lemna paucicostata

Stephen O. Duke, Antonio Evidente, Michele Fiore, Agnes M. Rimando, Franck E. Dayan,

Maurizio Vurro, Nicole Christiansen, Ralf Looser, Johannes Hutzler, Klaus Grossmann

Pest. Biochem. Physiol., 2011, 100, 41–50

 

  1. Analysis of phytotoxic fungal toxins from Ascochyta caulina liquid culture

Agnes M, Rimando, Michele Fiore, Antonio Evidente

Abstr. Pap. Am. Chem. S., 2010, 239, 96-99

 

  1. A new GC-MS method for the analysis of ascaulitoxin, its aglycone and 4-aminoproline from culture filtrates of Ascochita caulina

Michele Fiore, Agnes Rimando, Anna Andolfi and Antonio Evidente

Anal. Methods, 2010, 2, 159 - 163

 

  1. Synthesis of S-glycosyl amino acids and S-glycosilpeptides via photoinduced click thiol-ene coupling

Michele Fiore, Salvatore Pacifico, Mauro Lo Conte, Alberto Marra and Alessandro Dondoni

Tetrahedron Lett., 2011,  52 , 444–447

 

  1. Photoinduced Thiol Ene Coupling as a Click Ligation tool for Thiodisaccarides Synthesis

Michele Fiore, Alberto Marra and Alessandro Dondoni

  1. Org. Chem., 2009, 74, 4422 – 4425

 

  1. Single and Dual glycoside clustering around calix[4]arene scaffolds via click thiol ene and azide-alkyne cycloaddition

Michele Fiore, Angela Chambery, Alberto Marra and Alessandro Dondoni.

Org. Biomol. Chem., 2009, 7, 3910 - 3913

 

  1. Diplofuranones A and B, two Further New 4-Monosubstituted 2(3H)-dihydrofuranones Produced by Diplodia corticola,  a Fungus Pathogen of Cork Oak

Antonio Evidente, Anna Andolfi, Michele Fiore, Emanuela Spanu, Antonio Franceschini, and Lucia Maddau

Archiv. O. C., 2007, 7, 318 – 320

 

  1. Diplobifuranylones A and B, 5’-Monosubstituted Tetrahydro-2H-bifuranyl-5-ones Produced by Diplodia corticola, a Fungus Pathogen of Cork Oak

Antonio Evidente, Anna Andolfi, Michele Fiore, Emanuela Spanu, Lucia Maddau, Antonio Franceschini, Francesco Marras, and Andrea Motta

  1. Nat. Prod., 2006, 69, 671-674

 

  1. Chemical and biological characterisation of sapinopyridione, a phytotoxic 3,3,6-trisubstituted-2,4-pyridione produced by Sphaeropsis sapinea, a toxigenic pathogen of native and exotic conifers, and its derivatives

Antonio Evidente, Michele Fiore, Giovanni Bruno,Lorenzo Sparapano, Andrea Motta

Phytochemistry, 2006, 67, 1019–1028

 

  1. Occurence, isolation and biological activity of phytotoxic metabolites produced in vitro by Spaeropsis sapinea, pathogenic fungus of Pinus radiata

Annalisa Cabras, Maria A. Mannoni, Salvatorica Serra, Anna Andolfi, Michele Fiore and Antonio Evidente

Eur. J. Plant Path., 2006, 115, 187-193

 

  1. Stimulation of Orobanche ramosa seed germination by fusicoccin derivatives: A structure–activity relationship study

Antonio Evidente, Anna Andolfi, Michele Fiore, Angela Boari, Maurizio Vurro

Phytochemistry, 2006, 67, 19–26