Peter GOEKJIAN

Prof. Peter GOEKJIAN (PR1)

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04.72.44.81.83
06.88.71.72.03

2000 - Present : Professor (PR1), Université Claude Bernard Lyon 1
1994 - 2000 : Assistant Professor Mississippi State University
1991 - 1994 : Postdoctoral studies, University of Wisconsin (Prof. Edwin Vedejs)
1984 - 1991 : PhD in Organic Chemistry, Harvard University (Prof. Yoshito Kishi)

GALKEM, Srl, Via Italia, 46, Monza, Italy, December 2013. Co-founder. SME specializing in the development of pharmacologically active molecules, in particular for the development of mechanism-based therapies targeting oncogenic fusion proteins such as ALK.


1. M. Cheniour, D. Gueyrard, P. G. Goekjian, T. Granjon, O. Marcillat: A convenient and versatile synthesis of Laurdan-like fluorescent membrane probes: characterization of their fluorescence properties, RSC Adv. 2016, 5, 5547-5557.

2. Bach S., Comte A., Delehouzé C., Dimanche-Boitrel M-T., Goekjian P. et Mettey Y. (2015) Sibiriline derivatives for use for preventing and/or treating disorders associated with cellular necroptosis. Request for grant of a European patent, n°15306624.6 filed on October 13, 2015.

3. Bach S., Comte A., Delehouzé C., Dimanche-Boitrel M-T. and Goekjian P. (2015) N1- and N7-substituted sibiriline derivatives and their use as inhibitor of cellular necroptosis. Request for grant of a European patent, n°15306623.8 filed on October 13, 2015.

4. N. Gigant, S. Habib, M. Medoc, P. G. Goekjian, D. Gueyrard*, I. Gillaizeau*: Synthesis of exo-enamides from protected lactams using a modified Julia olefination reaction: application to the synthesis of spiroaminal fragments, Eur. J. Org. Chem. 2014, 6501-6506.

5. Rechfeld, F.; Gruber, P.; Kirchmair, J.; Boehler, M.; Hauser, N.; Hechenberger, G.; Garczarczyk, D.; Lapa , G. B.; Preobrazhenskaya , M. N.; Goekjian P. G.; Langer, T.; Hofmann, J. Thienoquinolines as Novel Disruptors of the PKCε/RACK2 Protein–Protein Interaction. J. Med. Chem. 2014, 57(8),3235-46.

6. Smadhi, Meriem; de Bentzmann, Sophie; Imberty, Anne; Gingras, Marc; Abderrahim, Raoudha; Goekjian, Peter G. Expeditive synthesis of trithiotriazine-cored glycoclusters and inhibition of Pseudomonas aeruginosa biofilm formation. Beilstein Journal of Organic Chemistry 2014, 10, 1981-1990.

7. Samuel Habib, Florent Larnaud, Emmanuel Pfund, Teresa Mena Barragán, Thierry Lequeux, Carmen Ortiz Mellet, Peter G. Goekjiana and David Gueyrard. “Synthesis of substituted exo-glucals via a modified Julia olefination and identification as selective β-glucosidase inhibitors” Org. Biomol. Chem. 2014, 12, 690-699.

8. Ring dihedral Principal Component Analysis of furanose conformation. C.Coiffier, C. Barberot, J.-M. Nuzillard, P. Goekjian, E. Henon and A. Haudrechy. Chapter 18 in Carbohydrate Chemistry Vol 40, 2014, 40, 378–400.

9. Carlo Gambacorti Passerini, Luca Moligni, Leonardo Scapozza, William Bisson, Peter, G. Goekjian, Joseph D’Attoma. "2-Acylaminothiazoles for the Treatment of Cancer (2-Acilamminotiazoli Per Il Trattamento Del Cancro)" Italian Patent Application, MI2013A001124, July 4th 2013. WO/2015/001024 PCT/EP2014/064197 4 July 2014.

10. Samuel Habib, Florent Larnaud, Emmanuel Pfund, Thierry Lequeux, Bernard Fenet, Peter G. Goekjian, and David Gueyrard. “Synthesis of Fluorinated exo-Glycals through Modified Julia Olefination.” European Journal of Organic Chemistry 2013, 2013(10), 1872-1875.

11. Loic Tomas, Benjamin Bourdon, Jean Claude Caille, David Gueyrard, and Peter G. Goekjian. “A Concise and Efficient Synthesis of Spiroketals - Application to the Synthesis of SPIKET-P and a Spiroketal from Bactrocera Species.” European Journal of Organic Chemistry 2013, 2013(5), 915-920.

12. Carlo Gambacorti Passerini, Luca Moligny, Leonardo Scapozza, Shaheen Ahmed, William Bisson, Peter, G. Goekjian, Sebastien Tardy, Alexandre Orsato, David Gueyrard, and Benoit Joseph. "Alpha-Carbolines for the Treatment of Cancer." Eur. Patent Application Eur. Patent Application EP 2662372 A1 13 Nov 2012, PCT WO 2013167730 A1 14 Nov. 2013.

13. Loic Tomas, Gustav Boije af Gennas, Marie Aude Hiebel, Peter Hampson, David Gueyrard, Beatrice Pelotier, Jari Yli-Kauhaluoma, Olivier Piva, Janet M. Lord, and Peter G. Goekjian, “Total Synthesis of Bistramide A and Its 36(Z) Isomers: Differential Effect on Cell Division, Differentiation, and Apoptosis.” Chem. Eur. J. 2012, 7452 – 7466.

14. Loïc Tomas, Thibault Bechet, Erwann Jeanneau, David Gueyrard, Peter G.Goekjian “Efficient Synthesis of the C1-C13 Fragment of Bistramide A.” Synlett 2012, 215-218.

15. Dominique Lafont, Joseph D'Attoma, Rejane Gomez, Peter G. Goekjian “Epoxidation of glycals with oxone-acetone-tetrabutylammonium hydrogen sulfate: a convenient access to simple β-D-glycosides and to α-D-mannosamine and D-talosamine donors.” Tetrahedron: Asymmetry 2011, 22, 1197-1204.

16. Cédric Schneider, David Goyard, David Gueyrard, Benoît Joseph and Peter G. Goekjian. "Synthesis of 2-, 3- and 4-Substituted Pyrido[2,3-b]indoles by C–N, C–O, and C–C(sp) Bond Formation" Eur. J. Org. Chem. 2010, 34, 6665–6677.

17. Loïc Tomas, David Gueyrard and Peter G. Goekjian. "Synthesis of the spiroketal fragment of bistramide A via an exocyclic enol ether" Tetrahedron Letters 2010, 51(35), 4599-4601.

18. Carlo Gambacorti Passerini, Luca Moligny, Leonardo Scapozza, Shaheen Ahmed, Goekjian, Peter, G.; Gueyrard, David; Popowycz, Florence; Joseph, Benoit; Schneider, Cedric; Garcia, Pierre. "Alpha-carboline inhibitors of nmp-alk, ret, and bcr-abl" Eur. Pat. Appl. EP 2161271 A1 March 10, 2010. PCT Int. Appl. WO 2010025872 A2 March 11, 2010

19. Carlo Gambacorti Passerini, Rosalind Helen Gunby, Alfonso Zambon, Leonardo Scapozza, Shaheen Ahmed, Peter G. Goekjian, David Gueyrard, Florence Popowycz, Cedric Schneider. "Preparation of heterocyclylthiazolylbenzene derivatives and analogs for use as antiproliferative agents" Eur. Pat. Appl. EP2107054 A1, October 7, 2009. PCT Int. Appl. WO2009121535 A2, October 8, 2009.

20. Philippe Belmont, Laurent Meijer, Philip Cohen, Amaury Patin, Johann Bosson, and Peter Goekjian, "Tetrahydrocyclopenta[c]acridine derivatives as kinase inhibitors and their therapeutic use" Fr. Demande FR 2926550 A1 July 24, 2009. PCT Int. Appl. WO 2009090623 A1 July 23, 2009.

21. Caroline Corbel, Rose Haddoub, Damien Guiffant, David Gueyrard, Jérôme Lemoine, Morgane Ratin, Laurent Meijer, Stephane Bach and Peter Goekjian. "Identification of potential cellular targets of aloisine A by affinity chromatography" Bioorganic and Medicinal Chemistry 2009, 17(15), 5572-5582.

22. Mahmoud Benltifa, Joseph M. Hayes, Sebastien Vidal, David Gueyrard, Peter G. Goekjian, Jean-Pierre Praly, Gregory Kizilis, Costas Tiraidis, Kyra-Melinda Alexacou, Evangelia D. Chrysina, Spyros E. Zographos, Demetres D. Leonidas, Georgios Archontis, and Nikos G. Oikonomakos. "Glucose-based spiro-isoxazolines: A new family of potent glycogen phosphorylase inhibitors" Bioorganic & Medicinal Chemistry 2009, 17(20), 7368-7380.

23. Cédric Schneider, David Gueyrard, Benoît Joseph and Peter G. Goekjian. "Chemoselective Functionalization of α-Carbolines at 2-, 3-, 4- and 6-positions by Suzuki-Miyaura Reactions" Tetrahedron 2009, 65(27), 5427-5437.

24. Rose Haddoub, David Gueyrard and Peter G. Goekjian. "Synthesis of C-linked immobilized analogs of Aloisine A by ‘click’ chemistry" Tetrahedron Letters 2009, 50, 741-744.

25. Mazen Sleiman, Jean-Manuel Raimundo, Annabelle Varrot, Peter G. Goekjian and Marc Gingras."Glycosylated asterisks are among the most potent low valency inducers of Concanavalin A aggregation" Chemical Communications 2008, 6507–6509.

26. Carole Lamy, Jérôme Lemoine, Denis Bouchu, Peter Goekjian, and Peter Strazewski. "Control over the Histidine-Glycine Ratio in Random Copolymers Generated from Aqueous Solutions of the Amino Acids, Carbonyldiimidazole and Chlorotrimethylsilane through Pulsed Addition of the Glycine Precursor into Polymerizing Histidine" ChemBioChem 2008, 9, 710 – 713.

27. Marie-Aude Hiebel, Béatrice Pelotier, Peter Goekjian and Olivier Piva. "2,6-Disubstituted Tetrahydropyrans by Tandem Cross-Metathesis-Iodocyclisation" Eur. J. Org. Chem. 2008, 713–720.

28. Matthieu Corbet, Benjamin Bourdon, David Gueyrard and Peter G. Goekjian. "A Julia olefination approach to the synthesis of functionalized enol ethers and their transformation into carbohydrate-derived spiroketals," Tetrahedron Letters 2008, 49(5), 750-754.

29. Benjamin Bourdon , Matthieu Corbet, Patrice Fontaine Peter G. Goekjian and David Gueyrard. "Synthesis of enol ethers via a Julia modified olefination of lactones: application to the preparation of tri- and tetrasubstituted exoglycals," Tetrahedron Letters 2008, 49(5), 747-749.

30. Kaïss Aouadi, Bénédicte Defaut, Peter G. Goekjian and David Gueyrard. "Synthesis of semicyclic dienes derived carbohydrate by Julia olefination on anomeric vinyl sulfones," Synlett 2007, (16), 2590-2592.

31. Carole Lamy, Johann Hofmann, Hélène Parrot-Lopez, and Peter Goekjian. "Synthesis of a fluoroalkene peptidomimetic precursor of N-acetyl-L-glutamyl-L-alanine," Tetrahedron Lett.2007, 48(35), 6177-6180.

32. Schneider, Cédric; Gueyrard, David; Popowycz, Florence; Joseph, Benoît; Goekjian, Peter G. Synthesis of 6-Substituted Pyrido[2,3-b]indoles by Electrophilic Substitution," Synlett 2007, 14, 2237-2241.

33. Anne-Sophie Bretonnet , Anne Jochum, Olivier Walker, Isabelle Krimm, Peter Goekjian , Olivier Marcillat , Jean-Marc Lancelin. "NMR Screening Applied to the Fragment-Based Generation of Inhibitors of Creatine Kinase Exploiting a New Interaction Proximate to the ATP Binding Site", J. Med. Chem. 2007, 50(8); 1865-1875.

34. Johannes Trapp, Anne Jochum, Rene Meier, Laura Saunders, Brett Marshall, Conrad Kunick, Eric Verdin, Peter Goekjian, Wolfgang Sippl, and Manfred Jung. "Adenosine mimetics as inhibitors of NAD + -dependent histone deacetylases - from kinase to sirtuin inhibition", J. Med. Chem. 2006, 49, 7307-7316.

35. Mahmoud Benltifa, Sebastien Vidal, Bernard Fenet, Moncef Msaddek, Peter G. Goekjian, Jean-Pierre Praly, Attila Brunyanszki, Tibor Docsa, Pal Gergely. "In search of glycogen phosphorylase inhibitors: 5-substituted 3-C- glucopyranosyl-1,2,4-oxadiazoles from  -D-glucopyranosyl cyanides upon cyclization of O-acylamidoxime intermediates." Eur. J. Org. Chem. 2006, 18, 4242-4256.

36. Mahmoud Benltifa, Sébastien Vidal, David Gueyrard, Peter G. Goekjian, Moncef Msaddek, and Jean-Pierre Praly. "1,3-Dipolar cycloaddition reactions on carbohydrate-based templates: synthesis of spiro-isoxazolines and 1,2,4-oxadiazoles as glycogen phosphorylase inhibitors." Tetrahedron Letters 2006, 47, 6143–6147.

37. Peter G. Goekjian. "Staurosporine as an early lead: an overview of kinase inhibitors inspired by the indolocarbazole alkaloids." Dosis 2006, 22, 124-151.

38. David Gueyrard, Patrice Fontaine and Peter G. Goekjian. "Synthesis of C-glucoside endo-glycals from C-glucosyl vinyl sulfones." Synthesis 2006, 1499-1503.

39. Tahar Belhadj and Peter G. Goekjian. "An amide orthoesterification route to N -(1'-alkylthio-glucopyranosyl)indoles." Tetrahedron Letters 2005, 46, 8117-8120.

40. David Gueyrard, Rose Haddoub, Amine Salem, Nassib Said Bacar, and Peter G. Goekjian. "Synthesis of Exomethylene Glycals Using a Modified Julia Olefination." Synlett 2005 (3), 520-522.

41. Wendong Wang, Pornpun Rattananakin, and Peter G. Goekjian. "Synthesis of N-Glycoside Analogs via Thionolactones." J. Carb. Chem. 2003, 22, 743-751.

42. Peter G. Goekjian, Alexander Wei, and Yoshito Kishi. "Conformational Analysis of C-Glycosides and Related Compounds: Programming Conformational Profiles of C- and O-Glycosides" in Carbohydrate-based Drug Discovery, Wong, C.-H. Ed., Wiley 2003. Chapter 11, pp. 305-340.

43. Goekjian, P.G.; Jirousek, M. R. “Protein Kinase C Inhibitors as Novel Anticancer Drugs.” Exp. Opin. Invest. Drugs 2001, 10, 2117-2140.

44. Wendong Wang, Guo-Zhang Wu, and Peter G. Goekjian. “Atypical Regioselectivity in the Electrochemical Reduction-Nucleophilic Substitution of Nitroanisole.” Eur. J. Org. Chem., 2000, 1517-1520.

45. P. G. Goekjian, G.-Z. Wu, S. Chen, L. Zhou, M. R. Jirousek, J. R. Gillig, L. M. Ballas, and J. T. Dixon. “The Synthesis of Fluorinated Macrocyclic Bis(indolyl)maleimides as Potential 19F-NMR Probes for PKC.” J. Org. Chem. 1999, 64, 4238-4246.

46. P. G. Goekjian and M. R. Jirousek. “Protein Kinase C in the Treatment of Disease: Signal transduction pathways, inhibitors, and agents in development.” Current Med. Chem. 1999, 6, 877-903.

47. M. R. Jirousek, P. G. Goekjian, and G.-Z. Wu. “Halo-Substituted Bisindolylmaleimide Protein Kinase C Inhibitors.” United States patent US 5936084 A, August 10, 1999. WO/1997/041127.

48. P. G. Goekjian, P. Lugo-Mas, S. L. Cable, J. O. Cole, J. W. White, D. J. Thompson, T. P. Dudley, M. R. Jirousek, J. T. Dixon, and L. M. Ballas, “Synthesis of Indole-Ring Fluorine-Labeled Analogs of LY333531, an Isoform-Selective Inhibitor of PKC.” J. Fluorine Chem. 1999, 98, 137-142.

49. W. Wang, G.-Z. Wu, and P. G. Goekjian. “Atypical Regioselectivity in the Electrochemical Reduction-Nucleophilic Substitution of Nitroanisole.” Eur. J. Org. Chem., 2000, 1517-1520.

50. E. Vedejs, R. J. Galante, and P. G. Goekjian. “A Thio-Diels-Alder Route to the Azocine Ring System. The Synthesis of (+/-)-Otonecine.” J. Am. Chem. Soc. 1998, 120, 3613-3622.

51. T. Haneda, P. G. Goekjian, S. H. Kim, and Y. Kishi. "Preferred Conformation of C-Glycosides. 10. Synthesis and Conformational Analysis of Carbon Trisaccharides" J. Org. Chem. 1992, 57, 490-498.

52. Y. Wang, P. G. Goekjian, D. M. Ryckman, W. H. Miller, S. A. Babirad, and Y. Kishi. "Preferred Conformation of C-Glycosides. 9. Conformational Analysis of 1,4-Linked Carbon Disaccharides" J. Org. Chem. 1992, 57, 482-489.

53. P. G. Goekjian, T.-C.g Wu, H.-Y. Kang, and Y. Kishi. "Preferred Conformation of C-Glycosides. 7. Preferred Conformation of Carbon Analogues of Isomaltose and Gentiobiose." J. Org. Chem. 1991, 56, 6422-6434.

54. P. G. Goekjian, T.-C. Wu, and Yoshito Kishi. "Preferred Conformation of C-Glycosides. 6. Conformational Similarity of Glycosides and Corresponding C-Glycosides." J. Org. Chem. 1991, 56, 6412-6422.

55. W. H. Miller, D. M. Ryckman, P. G. Goekjian, Y. Wang, and Y. Kishi. "Preferred Conformation of C-Glycosides. 5. Experimental Support for the Conformational Similarity between C- and O- Disaccharides." J. Org. Chem. 1988, 53, 5580-5582.

56. Y. Wang, P. G. Goekjian, D. M. Ryckman, and Y. Kishi. "Preferred Confor-mation of C-Glycosides. 4. Importance of 1,3-Diaxial-like Interactions around the Non-glycosidic Bond: Prediction and Experimental Proof." J. Org. Chem. 1988, 53, 4151-4153.

57. S. A. Babirad, Y. Wang, P. G. Goekjian, and Y. Kishi. "Preferred Conformation of C-Glycosides. 3. Preferred Conformation of Carbon Analogues of 1,4-Disaccharides." J. Org. Chem. 1987, 52, 4825-4827.

58. P. G. Goekjian, T.-C. Wu, H.-Y. Kang, and Y. Kishi. "Preferred Conformation of C-Glycosides. 2. Preferred Conformation of Carbon Analogues of Isomaltose and Gentiobiose." J. Org. Chem. 1987, 52, 4823-4825.

59. T.-C. Wu, P. G. Goekjian, and Y. Kishi. "Preferred Conformation of C-Glycosides. 1. Conformational Similarity of Glycosides and Corresponding C-Glycosides." J. Org. Chem. 1987, 52, 4819-4823.