Prof Pierre STRAZEWSKI (PR1)

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04 72 44 82 34 

2001 - Present : Professor, Université Claude Bernard Lyon 1
1996 - 2001 : Assistant Professor (Privat-Dozent), Université de Bâle
1990 - 1996 : Research Associate, Université de Bâle (HDR)
1988 - 1990 : Postdoctoral studies, University of Cambridge (Dr Olga Kennard)
1986 - 1988 : Assistant de Recherche, Université de Bâle (Prof. Christoph Tamm)
1981 - 1986 : PhD in Organic Chemistry, Université de Bâle (Prof. Christoph Tamm)

(64) Fiore, M.; Strazewski, P.
Bringing Prebiotic Nucleosides and Nucleotides Down to Earth.
Angew. Chem. Int. Ed. 2016, 55, 13930-13933
Zur präbiotischen Synthese von Nukleosiden und Nukleotiden
Angew. Chem. 2016, 128, 14134-14137


(63) Fiore, M.; Strazewski, P.
Prebiotic lipidic amphiphiles and condensing agents on the early Earth.
Life (Basel) 2016, 6, 17.
Open Access Article DOI:10.3390/life6020017


(62) Strazewski, P.
Amphiphilic Peptidyl-RNA, in:
DNA in Supra­molecular Chemistry and Nano­tech­no­logy. Stulz E., Clever G. H. (eds),
Wiley–VCH 2015, Chapter 4.3, pp 294–307, ISBN: 978-1-118-69686-6.
Description and TOC @ Wiley


(61) Strazewski, P.
Omne Vivum Ex Vivo ... Omne? How to feed an inanimate evolvable chemical system so as to let it self-evolve into increased complexity and life-like behaviour.
Isr. J. Chem. 2015, 55, 851-864.


(60) Strazewski, P.
RNA as major components in chemical evolvable systems, in:
Chemical Biology of Nucleic Acids. Fundamentals and Clinical Applications. Erdmann V. A., Mar­kie­wicz W. T., Barciszewski J. (eds.),
Series: RNA Technologies. Erdmann V. A., Barciszewski J. (series eds.),
Springer 2014, Chapter 1, pp 1–24, ISBN 978-3-642-54452-1
Free Preview @ Springer


(59) Isaad, A. L. C.; Carrara, P.; Stano, P.; Krishnakumar, K. S.; Lafont, D.; Zamboulis, A.; Buchet, R.; Bouchu, D.; Albrieux, F.; Strazewski, P.
A hydrophobic disordered peptide spontaneously anchors a covalently bound RNA hairpin to giant lipidic vesicles.
Org. Biomol. Chem. 2014, 12, 6363-6373.


(58) Shan Fung, A. W.; Ebhardt, H. A.; Krishnakumar, K. S.; Moore, J.; Xu, Z.; Strazewski, P.; Fahlman, R. P.
Probing the Leucyl/Phenylalanyl tRNA Protein Transferase Active Site with tRNA Substrate Analogues.
Protein Pept. Lett. 2014, 21, 603-614.


(57) Krishnakumar, K. S.; Michel, B. Y.; Nguyen-Trung, N. Q.; Fenet, B.; Strazewski, P.
Intrinsic pKa values of 3'-N-α-L-aminoacyl-3'-aminodeoxyadenosines determined by pH dependent 1H NMR in H2O.
Chem. Commun.2011, 47, 3290-3292.


(56) Krishnakumar, K. S.; Goudedranche, S.; Bouchu, D.; Strazewski, P.
The Shortest Synthetic Route to Puromycin Analogs using a Modified Robins Approach.
J. Org. Chem. 2011, 76, 2253-2256.


(55) Johansson, M.; Ieong, K.-W.; Trobro, S.; Strazewski, P.; Åqvist, J.; Pavlov, M. Y.; Ehrenberg, M.
pH-Sensitivity of the ribosomal peptidyl transfer reaction dependent on the identity of the A-site aminoacyl-tRNA.
Proc. Natl. Acad. Sci. USA 2011, 108, 79-84.
Open Access Article DOI:10.1073/pnas.1012612107


(54) Strazewski, P.
The relationship between difference and ratio and a proposal: equivalence of temperature and time, and the first spontaneous symmetry breaking.
J. Syst. Chem. 2010, 1, 11.
Open Access Article DOI:10.1186/1759-2208-1-11


(53) Zimak, P.; Terenzi, S.; Strazewski, P.
New concept for quantification of similarity relates entropy and energy of objects: First and Second Law entangled, group behavior of micro black holes expected.
J. Syst. Chem. 2010,1, 2.
Open Access Article DOI:10.1186/1759-2208-1-2


(52) Krishnakumar, K. S.; Strazewski, P.
Synthesis of a deoxyxylopuromycin analogue.
Synlett 2010, 1055-1058.
Open Acces Article DOI:10.1055/s-0029-1219436


(51) Michel, B. Y.; Strazewski, P.
Total Syntheses of a Conformationally Locked North-Type Methanocarba Puromycin Analogue and a Dinucleotide Derivative.
Chem.–Eur. J. 2009, 15, 6244-6257.


(50) Strazewski, P.
Adding to Hans Kuhn's thesis on the emergence of the genetic apparatus: Of the Darwinian advantage to be neither too soluble, nor too insoluble, neither too solid, nor completely liquid.
Colloids Surf.B 2009, 74, 419-425.


(49) Lamy, C.; Lemoine, J.; Bouchu, D.; Goekjian, P.; Strazewski, P.
Glutamate-glycine and histidine-glycine co-oligopeptides: batch co-oligomerization versus pulsed addition of N-carboxyanhydrides.
ChemBioChem 2008, 9, 710-713.


(48) Saneyoshi, H.; Michel, B. Y.; Choi, Y.; Strazewski, P.; Marquez, V. E.
Synthesis of Conformationally Locked Versions of Puromycin Analogues.
J. Org. Chem. 2008, 73, 9435-9438.


(47) Michel, B. Y.; Krishnakumar, K. S.; Strazewski, P.
Total synthesis of a xylo-Puromycin analog.
Nucleic Acids Symp. Ser. 2008, 52, 575-576.
Open Access Symposium Abstract DOI:10.1093/nass/nrn291


(46) Michel, B. Y.; Strazewski, P.
Total syntheses of a North methanocarba Puromycin analog and its dinucleotide derivative.
Nucleic Acids Symp. Ser. 2008, 52, 559-560.
Open Access Symposium Abstract DOI:10.1093/nass/nrn283


(45) Michel, B. Y.; Krishnakumar, K. S.; Johansson, M.; Ehrenberg, M.; Strazewski, P.
Structural and functional prerequisites for ribosomal nascent peptide acceptors: attempts to decipher the nature of the ribosome's catalysis of peptide bond formation.
Nucleic Acids Symp. Ser. 2008, 52, 33-34.
Open Access Symposium Abstract DOI:10.1093/nass/nrn017


(44) Michel, B. Y.; Krishnakumar, K. S.; Strazewski, P.
Synthesis of a xylo-puromycin analogue.
Synlett 2008, 2461-2464.
Open Access Article DOI:10.1055/s-2008-1078025


(43) Charafeddine, A.; Dayoub, W.; Chapuis, H.; Strazewski, P.
First synthesis of 2'-deoxyfluoropuromycin analogues: experimental insight into the mechanism of the Staudinger reaction.
Chem. Eur. J. 2007, 13, 5566-5584.


(42) Charafeddine, A.; Chapuis, H.; Strazewski, P.
Facile and Rapid Access to Inosine Puromycin Analogs through the Use of Adenylate Deaminase.
Org. Lett. 2007, 9, 2787-2790.


(41) Strazewski, P.
Question 6: How did translation occur?
Orig. Life Evol. Biosph. 2007, 37, 399-401.
Power Point Presentation Erice 2006

(40) Michel, B. Y.; Strazewski, P.
Synthesis of (–)-neplanocin A with the highest overall yield via an efficient Mitsunobu coupling.
Tetrahedron 2007, 63, 9836-9841.


(39) Lazar, A. N.; Coleman, A. W.; Terenzi, S.; Strazewski, P.
Observation of the formation of supported bilayers by amphiphilic peptidyl-RNA.
Chem. Commun. 2006, 63-65.


(38) Chapuis, H.; Strazewski, P.
Shorter puromycin analog synthesis by means of an efficient Staudinger-Vilarrasa coupling.
Tetrahedron 2006, 62, 12108-12115.


(37) Strazewski, P.
A propos "Channeling the future"
Chemical & Engineering News, 2004,82(9), 4-5, 45.


(36) Nguyen-Trung, N. Q.; Terenzi, S.; Scherer, G.; Strazewski, P.
High-Yield Immobilization of a Puromycin Analogue for the Solid Support Synthesis of Aminoacyl-tRNA Fragments.
Org. Lett. 2003, 5, 2603-2606.


(35) Terenzi, S.; Biała, E.; Nguyen-Trung, N. Q.; Strazewski, P.
Amphiphilic 3'-peptidyl-RNA conjugates.
Angew. Chem., Int. Ed. 2003, 42, 2909-2912.
Angew. Chem. 2003, 115, 3015–3018


(34) Nguyen-Trung, N. Q.; Botta, O.; Terenzi, S.; Strazewski, P.
A Practical Route to 3'-Amino-3'-deoxyadenosine Derivatives and Puromycin Analogues.
J. Org. Chem. 2003, 68, 2038-2041.


(33) Choi, Y.; George, C.; Strazewski, P.; Marquez, V. E.
Synthesis of a Conformationally Locked Version of Puromycin Amino Nucleoside.
Org. Lett. 2002, 4, 589-592.


(32) Strazewski, P.
Thermodynamic Correlation Analysis: Hydration and Perturbation Sensitivity of RNA Secondary Structures.
J. Am. Chem. Soc. 2002, 124, 3546-3554.


(31) Biała, E.; Strazewski, P.
Internally Mismatched RNA: pH and Solvent Dependence of the Thermal Unfolding of tRNAAla Acceptor Stem Microhairpins.
J. Am. Chem. Soc. 2002124, 3540-3545.


(30) Trung, N. Q. N.; Strazewski, P.; Olsson, M.; Ehrenberg, M.
The conformational space of nascent peptide-accepting 3'-aminoacyl ribonucleos(t)ides: 1H NMR data and ab initio calculations of puromycin and some synthetic analogs.
Nucleosides, Nucleotides & Nucleic Acids 2001, 20, 383-384.
Symposium Abstract DOI:10.1081/NCN-100002310
Free Abstract


(29) Strazewski, P.
W obronie chemii
Nauka 2000, 1, 109-125.
(Quarterly journal of the Polish Academy of Sciences, PAN)
Polski tekst z ilustracjami (PDF 10 MB)


(28) Moyroud, E.; Biała, E.; Strazewski, P.
Synthesis and enzymatic digestion of an RNA nonamer in both enantiomeric forms.
Tetrahedron 2000, 56, 1475-1484.


(27) Biała, E.; Botta, O.; Moyroud, E.; Strazewski, P.
Ribonucleosides, aminoacyl-, and peptidyl-RNA. Synthesis, thermodynamics, and structure.
Chimia 1999, 53, 226-227.
Open Access Document


(26) Strazewski, P.; Biała, E.; Gabriel, K.; McClain, W. H.
The relationship of thermodynamic stability at a G·U recognition site to tRNA aminoacylation specificity.
RNA 1999, 5, 1490-1494.
Open Access Article


(25) Gunzenhauser, S.; Biała, E.; Strazewski, P.
Tetraethylene glycol-derived spacer for oligonucleotide synthesis.
Nucleosides & Nucleotides 1999, 18, 1223-1224.
Symposium Abstract DOI:10.1080/07328319908044669


(24) Biała, E.; McClain, W.; Strazewski, P.
Thermodynamics of site-specific variant tRNAAla acceptor stem micro-hairpins.
Nucleosides & Nucleotides 1999, 18, 1575-1576.
Symposium Abstract DOI:10.1080/07328319908044788


(23) Botta, O.; Strazewski, P.
Synthesis of an alanyl adenosine analog.
Nucleosides & Nucleotides 1999, 18, 721-723.
Symposium Abstract DOI:10.1080/15257779908041553


(22) Moyroud, E.; Botta, O.; Strazewski, P.
L-Ribonucleosides for racemic RNA.
Nucleosides & Nucleotides 1999, 18, 693-695.
Symposium Abstract DOI:10.1080/15257779908041544


(21) Moyroud, E.; Strazewski, P.
L-Ribonucleosides from L-xylose.
Tetrahedron 199955, 1277-1284.


(20) Gunzenhauser, S.; Biała, E.; Strazewski, P.
Tetraethylene glycol-derived spacer for oligonucleotide synthesis.
Tetrahedron Lett. 1998, 39, 6277-6280.


(19) Botta, O.; Moyroud, E.; Lobato, C.; Strazewski, P.
Synthesis of 3'-azido- and 3'-amino-3'-deoxyadenosine in both enantiomeric forms.
Tetrahedron 199854, 13529-13546.


(18) Strazewski, P.
Braucht es ein Plädoyer für Chemie ?
Chimia 1997, 51, 69-75.
Dokument in deutscher Sprache
"A Pleading for Chemistry" Open Access Translation in English


(17) Amantea, A.; Henz, M.; Strazewski, P.
Synthesis of (15N2)[17O]urea, (15N2)[O2,O4-17O2]uridine, and (15N3)[O2-17O]cytidine.
Helv. Chim. Acta 1996, 79, 244-54.


(16) Strazewski, P.
Calculating the thermodynamics of weakly hydrogen-bonded complexes from heteronuclear NMR data: Base-pairing stabilities of a 5-methyl(15N2)[O2,O4-17O2]uridine (= (15N2)[O2,O4-17O2]ribosylthymine) derivative and structural implications.
Helv. Chim. Acta 1995, 78, 1112-43.


(15) Amantea, A.; Walser, M.; Sequin, U.; Strazewski, P.
Synthesis and 15N and 17O NMR spectra of 5-methyl(15N2)[O2,O4-17O2]uridine (=(15N2)[O2,O4-17O2]ribosylthymine).
Helv. Chim. Acta 1995, 78, 1106-11.


(14) Niemann, A. C.; Meyer, M.; Engeloch, T.; Botta, O.; Hädener, A.; Strazewski, P.
Biosynthesis production of [N2,1,3,7,9-15N]guanosine and [1,3,7,9-15N]inosine and conversion into [N6,1,3,7,9-15N]adenosine for structure elucidation of RNA by heteronuclear NMR.
Helv. Chim. Acta 199578, 421-39.

(13) Cruse, W. B. T.; Saludjian, P.; Biala, E.; Strazewski, P.; Prange, T.; Kennard, O.
Structure of a mispaired RNA double helix at 1.6-Å resolution and implications for the prediction of RNA secondary structure.
Proc. Natl. Acad. Sci. USA 1994, 91, 4160-4.
Open Access Article PubMed ID 7514296


(12) Stolz, F.; Strazewski, P.; Tamm, C.; Neuburger, M.; Zehnder, M.
New chiral α-benzyloxyacryliron(II) complex for asymmetric synthesis of α,α-dialkyl-α-hydroxycarbonyl compounds
Angew. Chem. Int. Ed. Engl. 1992, 31, 193-195.
Neuer chiraler α-Benzyloxyacryl-Eisen(II)-Komplex zur asymmetrischen Synthese von α,α-Dialkyl-α-hydroxycarbonylverbindungen.
Angew. Chem. 1992, 104, 225–227


(11) Eschenhof, H.; Strazewski, P.; Tamm, C.
A new synthesis of 3-deazathymidine and of a related phosphoramidite synthon.
Tetrahedron 1992, 48, 6225-30.


(10) Kienzler, T.; Strazewski, P.; Tamm, C.
A new synthesis of coprine and O-ethylcoprine.
Helv. Chim. Acta 1992, 75, 1078-84.


(9) Strazewski, P.
Psoralen mutagenesis by transient misalignment?
J. Theor. Biol. 1991, 151, 429-31.
Open Access Article DOI:10.1016/S0022-5193(05)80390-X


(8) Kienzler, T.; Strazewski, P.; Tamm, C.
Synthesis of 1-aminocyclopropanol by anodic oxidation.
Synlett 1991, 737-8.
Open Access Article DOI:10.1055/s-1991-34757


(7) Strazewski, P.; Tamm, C.
Replication experiments with nucleotide base analogs.
Angew. Chem. Int. Ed. 1990, 29, 36-57.
Replikationsexperimente mit Nukleotidbasen-Analoga.
Angew. Chem. 1990, 102, 37–59

(6) Strazewski, P.
The biological equilibrium of base pairs.
J. Mol. Evol. 1990, 30, 116-24.


(5) Strazewski, P.
Mispair formation in DNA can involve rare tautomeric forms in the template.
Nucleic Acids Res. 198816, 9377-98.
Open Access Article DOI:10.1093/nar/16.20.9377 


(4) Strazewski, P.
Nucleosides and nucleotides: Part 28 [1]. Carbon-13 NMR spectra of 2'-deoxycytidine and 3-deaza-2'-deoxycytidine.
Nucleic Acids Res. 1988, 16, 5191.
Open Access Article DOI:10.1093/nar/16.11.5191


(3) Strazewski, P.; Tamm, C.
A simple synthesis of 1-aminocyclopropane-1-carboxylic acid.
Synthesis 1987, 298-9.
Open Access Article DOI:10.1055/s-1987-27925


(2) Strazewski, P.; Tamm, C.
Insight into the behavior of a lithium enolate in solution.
Helv. Chim. Acta 1986, 69, 1041-51.


(1) Schmidlin, T.; Gamboni, R.; Strazewski, P.; Tamm, C.
Approaches to the synthesis of cytochalasans. Part 5. Studies on the selectivity of the Diels-Alder reaction leading to the tetrahydroisoindolinone subunit.
Helv. Chim. Acta 1983, 66, 1796-805.