2016

Abda, H.; Aouadi, K.; Brahmi, J.; Msaddek, M.; Vidal, S. Unexpected Synthesis of Aziridines under Cu(I) Catalyzed Kinugasa Conditions Assisted by Microwave Irradiation C. R. Chimie 2016, 19, 274-277.

 

Boukerb, A. M.; Decor, A.; Ribun, S.; Tabaroni, R.; Rousset, A.; Commin, L.; Buff, S.; Doleans-Jordheim, A.; Vidal, S.; Varrot, A.et al. Genomic Rearrangements and Functional Diversification of Leca and Lecb Lectin-Coding Regions Impacting the Efficacy of Glycomimetics Directed against Pseudomonas aeruginosa Front. Microbiol. 2016, 7, 811.

 

Brahmi, J.; Aouadi, K.; Msaddek, M.; Praly, J.-P.; Vidal, S. A Stereoselective Method for the Synthesis of Enantiopure 3-Substituted 4-Hydroxyproline Derivatives Via 1,3-Dipolar Cycloadditions C. R. Chimie 2016, 19, 933-935.

 

Brahmi, J.; Nasri, S.; Aouadi, K.; Jeanneau, E.; Vidal, S.; Msaddek, M. Crystal Structure of 5-Chloromethyl-N-Methyl-4-[(4-Phenyl-1,2,3-Triazol-1-Yl)Methyl]Isoxazolidine-3-Carboxamide Acta Cryst. Sect. E 2016, 72, 378-381.

 

Buffet, K.; Nierengarten, I.; Galanos, N.; Gillon, E.; Holler, M.; Imberty, A.; Matthews, S. E.; Vidal, S.; Vincent, S. P.; Nierengarten, J.-F. Pillar[5]Arene-Based Glycoclusters: Synthesis and Multivalent Binding to Pathogenic Bacterial Lectins Chem. Eur. J. 2016, 22, 2955-2963.

 

Cheniour, M.; Gueyrard, D.; Goekjian, P. G.; Granjon, T.; Marcillat, O. A Convenient and Versatile Synthesis of Laurdan-Like Fluorescent Membrane Probes: Characterization of Their Fluorescence Properties RSC Adv. 2016, 6, 5547-5557.

 

Donnier-Maréchal, M.; Vidal, S. Glycogen Phosphorylase Inhibitors: A Patent Review (2013 - 2015) Exp. Opin. Ther. Patents 2016, 26, 199-212.

Dussart, N.; Trinh, H. V.; Gueyrard, D. Modified Julia Olefination on Anhydrides: Extension and Limitations. Application to the Synthesis of Maculalactone B Org. Lett. 2016, 18, 4790-4793.

 

Fiore, M.; Strazewski, P. Bringing Prebiotic Nucleosides and Nucleotides Down to Earth Angew. Chem. Int. Ed. 2016, 55, 13930-13933.

 

Fiore, M.; Strazewski, P. Prebiotic Lipidic Amphiphiles and Condensing Agents on the Early Earth Life 2016, 6, 17.

 

Galanos, N.; Gillon, E.; Imberty, A.; Matthews, S. E.; Vidal, S. Pentavalent Pillar[5]Arene-Based Glycoclusters and Their Multivalent Binding to Pathogenic Bacterial Lectins Org. Biomol. Chem. 2016, 14, 3476-3481.

 

Goyard, D.; Kónya, B.; Chajistamatiou, A. S.; Chrysina, E. D.; Leroy, J.; Balzarin, S.; Tournier, M.; Tousch, D.; Petit, P.; Duret, C.et al. Glucose-Derived Spiro-Isoxazolines Are Anti-Hyperglycemic Agents against Type 2 Diabetes through Glycogen Phosphorylase Inhibition Eur. J. Med. Chem. 2016, 108, 444-454.

 

Mologni, M.; Gambacorti-Passerini, C.; Goekjian, P.; Scapozza, L. RET kinase inhibitors: a review of recent patents (2012-2015) Exp. Opin. Ther. Patents 2016, doi 10.1080/13543776.2017.1238073.

 

Trinh, H. V.; Perrin, L.; Goekjian, P. G.; Gueyrard, D. Development of a Modified Julia Olefination of Imides for the Synthesis of Alkaloids Eur. J. Org. Chem. 2016, 2944-2953.

 

Vidal, S. Glycofullerenes: Sweet Fullerenes Vanquish Viruses Nat. Chem. 2016, 8, 4-6.

 

Wang, S.; Dupin, L.; Noël, M.; Carroux, C. J.; Renaud, L.; Géhin, T.; Meyer, A.; Souteyrand, E.; Vasseur, J.-J.; Vergoten, G.et al. Toward the Rational Design of Galactosylated Glycoclusters That Target Pseudomonas aeruginosa Lectin a (LecA): Influence of Linker Arms That Lead to Low-Nanomolar Multivalent Ligands Chem. Eur. J. 2016, 22, 11785-11794.

2015

Cecioni, S.; Imberty, A.; Vidal, S. Glycomimetics Versus Multivalent Glycoconjugates for the Design of High Affinity Lectin Ligands Chem. Rev. 2015, 115, 525-561.

 

Donnier-Maréchal, M.; Goyard, D.; Folliard, V.; Docsa, T.; Gergely, P.; Praly, J.-P.; Vidal, S. 3-Glucosylated 5-Amino-1,2,4-Oxadiazoles: Synthesis and Evaluation as Glycogen Phosphorylase Inhibitors Beilstein J. Org. Chem. 2015, 11, 499-503.

 

Goyard, D.; Docsa, T.; Gergely, P.; Praly, J.-P.; Vidal, S. Synthesis of 4-Amidomethyl-1-Glucosyl-1,2,3-Triazoles and Evaluation as Glycogen Phosphorylase Inhibitors Carbohydr. Res. 2015, 402, 245-251.

 

Habib, S.; Gueyrard, D. Modified Julia Olefination on Sugar-Derived Lactones: Synthesis of Difluoro-Exo-Glycals Eur. J. Org. Chem. 2015, 871-875.

Le Guen, C.; Mena-Barragan, T.; Ortiz Mellet, C.; Gueyrard, D.; Pfund, E.; Lequeux, T. Fluorinated Hydroxypiperidines as Selective b-Glucosidase Inhibitors Org. Biomol. Chem. 2015, 13, 5983-5996.

 

Ligeour, C.; Dupin, L.; Angeli, A.; Vergoten, G.; Vidal, S.; Meyer, A.; Souteyrand, E.; Vasseur, J.-J.; Chevolot, Y.; Morvan, F. Importance of Topology for Glycocluster Binding to Pseudomonas Aeruginosa and Burkholderia Ambifaria Bacterial Lectins Org. Biomol. Chem. 2015, 13, 11244-11254.

 

Ligeour, C.; Vidal, O.; Dupin, L.; Casoni, F.; Gillon, E.; Meyer, A.; Vidal, S.; Vergoten, G.; Lacroix, J.-M.; Souteyrand, E.et al. Mannose-Centered Aromatic Galactoclusters Inhibit the Biofilm Formation of Pseudomonas aeruginosa Org. Biomol. Chem. 2015, 13, 8433-8444.

 

Pfund, E.; Lequeux, T.; Gueyrard, D. Synthesis of Fluorinated and Trifluoromethyl-Substituted Alkenes through the Modified Julia Olefination: An Update Synthesis 2015, 47, 1534-1546.

 

Strazewski, P. Omne Vivum Ex Vivo ... Omne? How to Feed an Inanimate Evolvable Chemical System So as to Let It Self-Evolve into Increased Complexity and Life-Like Behaviour Isr. J. Chem. 2015, 55, 851-864.

 

Wang, S.; Cuesta-Seijo, J. A.; Striebeck, A.; Lafont, D.; Palcic, M. M.; Vidal, S. Design of Glycosyltransferase Inhibitors: Serine Analogues as Pyrophosphate Surrogates? ChemPlusChem 2015, 80, 1525-1532.

2014

Coiffier, C.; Barberot, C.; Nuzillard, J.-M.; Goekjian, P.; Henon, E.; Haudrechy, A., Ring dihedral principal component analysis of furanose conformation. Carbohydr. Chem. 2014, 40, 378-400.

 

Isaad, A. L. C.; Carrara, P.; Stano, P.; Krishnakumar, K. S.; Lafont, D.; Zamboulis, A.; Buchet, R.; Bouchu, D.; Albrieux, F.; Strazewski, P., A hydrophobic disordered peptide spontaneously anchors a covalently bound RNA hairpin to giant lipidic vesicles. Org. Biomol. Chem. 2014, 12, 6363-6373.

 

Habib, S.; Larnaud, F.; Pfund, E.; Mena Barragan, T.; Lequeux, T.; Ortiz Mellet, C.; Goekjian, P. G.; Gueyrard, D., Synthesis of substituted exo-glucals via a modified Julia olefination and identification as selective β-glucosidase inhibitors. Org. Biomol. Chem. 2014, 12, 690-699.

 

Goyard, D.; Chajistamatiou, A. S.; Sotiropoulou, A. I.; Chrysina, E. D.; Praly, J.-P.; Vidal, S., Efficient Atropodiastereoselective Access to 5,5′-Bis-1,2,3-triazoles: Studies on 1-Glucosylated 5-Halogeno 1,2,3-Triazoles and Their 5-Substituted Derivatives as Glycogen Phosphorylase Inhibitors. Chem. Eur. J. 2014, 20, 5423-5432.

 

Gigant, N.; Habib, S.; Medoc, M.; Goekjian, P. G.; Gueyrard, D.; Gillaizeau, I., Synthesis of exo-Enamides from Protected Lactams Using a Modified Julia Olefination Reaction: Application to the Synthesis of Spiroaminal Fragments. Eur. J. Org. Chem. 2014, 6501-6506.

 

Gerland, B.; Goudot, A.; Ligeour, C.; Pourceau, G.; Meyer, A.; Vidal, S.; Gehin, T.; Vidal, O.; Souteyrand, E.; Vasseur, J.-J.; Chevolot, Y.; Morvan, F., Structure Binding Relationship of Galactosylated Glycoclusters toward Pseudomonas aeruginosa Lectin LecA Using a DNA-Based Carbohydrate Microarray. Bioconjugate Chem. 2014, 25, 379-392.

 

Smadhi, M.; de Bentzmann, S.; Imberty, A.; Gingras, M.; Abderrahim, R.; Goekjian, P. G., Expeditive synthesis of trithiotriazine-cored glycoclusters and inhibition of Pseudomonas aeruginosa biofilm formation. Beilstein J. Org. Chem. 2014, 10, 1981-1990.

 

Wang, S.; Shen, D. L.; Lafont, D.; Vercoutter-Edouart, A.-S.; Mortuaire, M.; Shi, Y.; Maniti, O.; Girard-Egrot, A.; Lefebvre, T.; Pinto, B. M.; Vocadlo, D.; Vidal, S., Design of glycosyltransferase inhibitors targeting human O-GlcNAc transferase (OGT). Med. Chem. Commun. 2014, 5, 1172-1178.

 

Wang, S.; Galanos, N.; Rousset, A.; Buffet, K.; Cecioni, S.; Lafont, D.; Vincent, S. P.; Vidal, S., Fucosylation of triethyleneglycol-based acceptors into "clickable" a-fucosides. Carbohydr. Res. 2014, 395, 15-18.

 

Tardy, S.; Orsato, A.; Mologni, L.; Bisson, W. H.; Donadoni, C.; Gambacorti-Passerini, C.; Scapozza, L.; Gueyrard, D.; Goekjian, P. G., Synthesis and biological evaluation of benzo[4,5]imidazo[1,2-c]pyrimidine and benzo[4,5]imidazo[1,2-a]pyrazine derivatives as anaplastic lymphoma kinase inhibitors. Bioorg. Med. Chem. 2014, 22, 1303-1312.

 

Shan Fung, A. W.; Ebhardt, H. A.; Krishnakumar, K. S.; Moore, J.; Xu, Z.; Strazewski, P.; Fahlman, R. P., Probing the Leucyl/Phenylalanyl tRNA Protein Transferase Active Site with tRNA Substrate Analogues. Protein Pept. Lett. 2014, 21, 603-614.

 

Rechfeld, F.; Gruber, P.; Kirchmair, J.; Boehler, M.; Hauser, N.; Hechenberger, G.; Garczarczyk, D.; Lapa, G. B.; Preobrazhenskaya, M. N.; Goekjian, P.; Langer, T.; Hofmann, J., Thienoquinolines as Novel Disruptors of the PKCε/RACK2 Protein-Protein Interaction. J. Med. Chem. 2014, 57, 3235-3246.

2013

Habib, S.; Larnaud, F.; Pfund, E.; Lequeux, T.; Fenet, B.; Goekjian, P. G.; Gueyrard, D., Synthesis of Fluorinated exo-Glycals through Modified Julia Olefination. Eur. J. Org. Chem. 2013, 1872-1875.

 

Ligeour, C.; Audfray, A.; Gillon, E.; Meyer, A.; Galanos, N.; Vidal, S.; Vasseur, J.-J.; Imberty, A.; Morvan, F., Synthesis of branched-phosphodiester and mannose-centered fucosylated glycoclusters and their binding studies with Burkholderia ambifaria lectin (BambL). RSC Adv. 2013, 3, 19515-19524.

 

Sicard, D.; Chevolot, Y.; Souteyrand, E.; Imberty, A.; Vidal, S.; Phaner-Goutorbe, M., Molecular arrangement between multivalent glycocluster and Pseudomonas aeruginosa LecA (PA-IL) by atomic force microscopy: influence of the glycocluster concentration. J. Mol. Recognit. 2013, 26, 694-699.

 

Tomas, L.; Bourdon, B.; Caille, J. C.; Gueyrard, D.; Goekjian, P. G., A Concise and Efficient Synthesis of Spiroketals - Application to the Synthesis of SPIKET-P and a Spiroketal from Bactrocera Species. Eur. J. Org. Chem. 2013, 915-920.

 

Wang, S.; Cuesta-Seijo, J. A.; Lafont, D.; Palcic, M. M.; Vidal, S., Design of Glycosyltransferase Inhibitors: Pyridine as a Pyrophosphate Surrogate. Chem. Eur. J. 2013, 19, 15346-15357.

 

Wang, S.; Lafont, D.; Rahkila, J.; Picod, B.; Leino, R.; Vidal, S., Glycosylation of "basic" alcohols: methyl 6-(hydroxymethyl)picolinate as a case study. Carbohydr. Res. 2013, 372, 35-46.

 

Goudot, A.; Pourceau, G.; Meyer, A.; Gehin, T.; Vidal, S.; Vasseur, J.-J.; Morvan, F.; Souteyrand, E.; Chevolot, Y., Quantitative analysis (Kd and IC50) of glycoconjugates interactions with a bacterial lectin on a carbohydrate microarray with DNA Direct Immobilization (DDI). Biosens. Bioelectron. 2013, 40, 153-160.

2012

Goyard, D.; Praly, J.-P.; Vidal, S., Synthesis of 5-halogenated 1,2,3-triazoles under stoichiometric Cu(I)-mediated azide-alkyne cycloaddition (CuAAC or "Click Chemistry"). Carbohydr. Res. 2012, 362, 79-83.

 

Tomas, L.; Boije af Gennaes, G.; Hiebel, M. A.; Hampson, P.; Gueyrard, D.; Pelotier, B.; Yli-Kauhaluoma, J.; Piva, O.; Lord, J. M.; Goekjian, P. G., Total Synthesis of Bistramide A and Its 36(Z) Isomers: Differential Effect on Cell Division, Differentiation, and Apoptosis. Chem. Eur. J. 2012, 18, 7452-7466.

 

Tomas, L.; Bechet, T.; Jeanneau, E.; Gueyrard, D.; Goekjian, P. G., Efficient synthesis of the C1-C13 fragment of bistramide A. Synlett 2012, 23, 215-218.

 

Tite, T.; Tomas, L.; Docsa, T.; Gergely, P.; Kovensky, J.; Gueyrard, D.; Wadouachi, A., Synthesis of N-aryl spiro-sulfamides as potential glycogen phosphorylase inhibitors. Tetrahedron Lett. 2012, 53, 959-961.

 

Morvan, F.; Vidal, S.; Souteyrand, E.; Chevolot, Y.; Vasseur, J.-J., DNA glycoclusters and DNA-based carbohydrate microarrays: From design to applications. RSC Adv.2012, 2, 12043-12068.

 

Morvan, F.; Chevolot, Y.; Zhang, J.; Meyer, A.; Vidal, S.; Praly, J.-P.; Vasseur, J.-J.; Souteyrand, E., Glycoarray by DNA-directed immobilization. Methods Mol. Biol. 2012, 808, 195-219.

 

Goyard, D.; Baron, M.; Skourti, P. V.; Chajistamatiou, A. S.; Docsa, T.; Gergely, P.; Chrysina, E. D.; Praly, J.-P.; Vidal, S., Synthesis of 1,2,3-triazoles from xylosyl and 5-thioxylosyl azides: evaluation of the xylose scaffold for the design of potential glycogen phosphorylase inhibitors. Carbohydr. Res. 2012, 364, 28-40.

 

Gerland, B.; Goudot, A.; Pourceau, G.; Meyer, A.; Vidal, S.; Souteyrand, E.; Vasseur, J.-J.; Chevolot, Y.; Morvan, F., Synthesis of Homo- and Heterofunctionalized Glycoclusters and Binding to Pseudomonas aeruginosa Lectins PA-IL and PA-IIL. J. Org. Chem. 2012, 77, 7620-7626.

 

Gerland, B.; Goudot, A.; Pourceau, G.; Meyer, A.; Dugas, V.; Cecioni, S.; Vidal, S.; Souteyrand, E.; Vasseur, J.-J.; Chevolot, Y.; Morvan, F., Synthesis of a Library of Fucosylated Glycoclusters and Determination of their Binding toward Pseudomonas aeruginosa Lectin B (PA-IIL) Using a DNA-Based Carbohydrate Microarray. Bioconjugate Chem. 2012, 23, 1534-1547.

 

Abda, H.; Aouadi, K.; Gueyrard, D.; Praly, J.-P.; Msaddek, M., Study of the Regio- and Stereoselectivity of [3+2] Cycloaddition of Nitrile Oxides to Various Racemic 3-acyloxy and 3-hydroxybut-1-enes. Lett. Org. Chem. 2012, 9, 96-100.

2011

Lafont, D.; D'Attoma, J.; Gomez, R.; Goekjian, P. G., Epoxidation of glycals with oxone-acetone-tetrabutylammonium hydrogen sulfate: a convenient access to simple β-D-glycosides and to α-D-mannosamine and D-talosamine donors. Tetrahedron: Asymmetry 2011, 22, 1197-1204.

 

Vedala, H.; Chen, Y.; Cecioni, S.; Imberty, A.; Vidal, S.; Star, A., Nanoelectronic Detection of Lectin-Carbohydrate Interactions Using Carbon Nanotubes. Nano Lett. 2011, 11, 170-175.

 

Soomro, Z. H.; Cecioni, S.; Blanchard, H.; Praly, J.-P.; Imberty, A.; Vidal, S.; Matthews, S. E., CuAAC synthesis of resorcin[4]arene-based glycoclusters as multivalent ligands of lectins. Org. Biomol. Chem. 2011, 9, 6587-6597.

 

Sicard, D.; Cecioni, S.; Iazykov, M.; Chevolot, Y.; Matthews, S. E.; Praly, J.-P.; Souteyrand, E.; Imberty, A.; Vidal, S.; Phaner-Goutorbe, M., AFM investigation of Pseudomonas aeruginosa lectin LecA (PA-IL) filaments induced by multivalent glycoclusters. Chem. Commun. 2011, 47, 9483-9485.

 

Pourceau, G.; Chevolot, Y.; Goudot, A.; Giroux, F.; Meyer, A.; Moulés, V.; Lina, B.; Cecioni, S.; Vidal, S.; Yu, H.; Chen, X.; Ferraris, O.; Praly, J.-P.; Souteyrand, E.; Vasseur, J.-J.; Morvan, F., Measurement of Enzymatic Activity and Specificity of Human and Avian Influenza Neuraminidases from Whole Virus by Glycoarray and MALDI-TOF Mass Spectrometry. ChemBioChem 2011, 12, 2071-2080.

 

Krishnakumar, K. S.; Michel, B. Y.; Nguyen-Trung, N. Q.; Fenet, B.; Strazewski, P., Intrinsic pKa values of 3'-N-α-L-aminoacyl-3'-aminodeoxyadenosines determined by pH dependent 1H NMR in H2O. Chem. Commun. 2011, 47, 3290-3292.

 

Krishnakumar, K. S.; Goudedranche, S.; Bouchu, D.; Strazewski, P., The Shortest Synthetic Route to Puromycin Analogs using a Modified Robins Approach. J. Org. Chem. 2011, 76, 2253-2256.

 

Johansson, M.; Ieong, K.-W.; Trobro, S.; Strazewski, P.; Åqvist, J.; Pavlov, M. Y.; Ehrenberg, M., pH-sensitivity of the ribosomal peptidyl transfer reaction dependent on the identity of the A-site aminoacyl-tRNA. Proc. Natl. Acad. Sci. U.S.A. 2011, 108, 79-84.

2010

Gueyrard, D.; Iori, R.; Tatibouët, A.; Rollin, P., Glucosinolate Chemistry: Synthesis of O-Glycosylated Derivatives of Glucosinalbin. Eur. J. Org. Chem. 2010, 3657-3664.

 

Gueyrard, D.; Tlegenov, R. T.; Steinbruckner, S.; Perly, B.; Rollin, P., Synthesis of new derivatives of 11-thiolupinine. J. Sulfur Chem. 2010, 31, 493-498.

 

Krishnakumar, K. S.; Strazewski, P., Synthesis of a deoxyxylopuromycin analogue. Synlett 2010, 1055-1058.

 

Nierengarten, J.-F.; Iehl, J.; Oerthel, V.; Holler, M.; Illescas, B. M.; Munoz, A.; Martin, N.; Rojo, J.; Sanchez-Navarro, M.; Cecioni, S.; Vidal, S.; Buffet, K.; Durka, M.; Vincent, S. P., Fullerene sugar balls. Chem. Commun. 2010, 46, 3860-3862.

 

Praly, J.-P.; Vidal, S., Inhibition of Glycogen Phosphorylase in the Context of Type 2 Diabetes, with Focus on Recent Inhibitors Bound at the Active Site. Mini-Rev. Med. Chem. 2010, 10, 1102-1126.

 

Schneider, C.; Goyard, D.; Gueyrard, D.; Joseph, B.; Goekjian, P. G., Synthesis of 2-, 3-, and 4-Substituted Pyrido[2,3-b]indoles by C-N, C-O, and C-C(sp) Bond Formation. Eur. J. Org. Chem. 2010, 6665-6677.

 

Goyard, D.; Telligmann, S. M.; Goux-Henry, C.; Boysen, M. M. K.; Framery, E.; Gueyrard, D.; Vidal, S., Carbohydrate-based spiro bis(isoxazolines): synthesis and evaluation in asymmetric catalysis. Tetrahedron Lett. 2010, 51, 374-377.

 

Zimak, P.; Terenzi, S.; Strazewski, P., New concept for quantification of similarity relates entropy and energy of objects: First and Second Law entangled, group behavior of micro black holes expected. J. Syst. Chem. 2010, 1, 2.

 

Tomas, L.; Gueyrard, D.; Goekjian, P. G., Synthesis of the spiroketal fragment of bistramide A via an exocyclic enol ether. Tetrahedron Lett. 2010, 51, 4599-4601.

 

Strazewski, P., The relationship between difference and ratio and a proposal: equivalence of temperature and time, and the first spontaneous symmetry breaking. J. Syst. Chem. 2010, 1, 11.

 

Schleiss, J.; Cerniauskaite, D.; Gueyrard, D.; Iori, R.; Rollin, P.; Tatibouët, A., Thioimidate N-Oxides: From Nature to Synthetic Pathways. Synlett 2010, 725-728.

Brevets

Gambacorti-Passerini, C.; Mologni, L.; Scapozza, L.; Bisson, W.; Goekjian, P.; D’Attoma, J.; 2-Acylaminothiazole derivatives as ALK inhibitors and their preparation and use for the treatment of cancer, WO2015001024A1, 2015.

Morvan, F.; Vasseur, J.-J.; Ligeour, C.; Chevolot, Y.; Souteyrand, E.; Vidal, O.; Goudot, A.; Vidal, S.; Glycoclusters and their pharmaceutical use as antibacterials WO2015040209A1, 2015.

 

Bach, S.; Comte, A.; Delehouzé, C.; Dimanche-Boitrel, M-T.; Goekjian, P.; Mettey, Y. (2015) Sibiriline derivatives for use for preventing and/or treating disorders associated with cellular necroptosis. European patent, n°15306624.6 filed on October 13, 2015. PCT filed October 13, 2016

 

Bach, S.; Comte, A.; Delehouzé, C.; Dimanche-Boitrel, M-T.; Goekjian, P. (2015) N1- and N7-substituted sibiriline derivatives and their use as inhibitor of cellular necroptosis. EP 15306623.8 filed on October 13, 2015. PCT filed October 13, 2016