Towards CF3S Group: From Trifluoromethylation of Sulfides to Direct Trifluoromethylthiolation.
F. Toulgoat, T. Billard
in Modern Synthesis Processes and Reactivity of Fluorinated Compounds: Progress in Fluorine Science (Eds.: H. Groult, F. Leroux, A. Tressaud), Elsevier Science, London, United Kingdom, 2017, pp. 141-179. (link)


Electrophilic Trifluoromethyl- and Fluoroalkylselenolation of Organometallic Reagents
Q. Glenadel, E. Ismalaj, T. Billard
Eur. J. Org. Chem. 2017, 530-533. (link)


Superacid-Catalyzed Trifluoromethylthiolation of Aromatic Amines
L. J. C. Bonazaba Milandou, H. Carreyre, S. Alazet, G. Greco, A. Martin-Mingot, C. Nkounkou Loumpangou, J.-M. Ouamba, F. Bouazza, T. Billard, S. Thibaudeau
Angew. Chem. Int. Ed. 201756, 169-172. (link)


Benzyltrifluoromethyl (or Fluoroalkyl) Selenide: Reagent for Electrophilic Trifluoromethyl (or Fluoroalkyl) Selenolation
Q. Glenadel, E. Ismalaj, T. Billard
J. Org. Chem. 2016, 81, 8268-8275.(link)


Synthetic Approaches to Trifluoromethoxy-Substituted Compounds
A. Tlili, F. Toulgoat, T. Billard
Angew. Chem. Int. Ed. 2016, 55, 11726-11735.(link)


Copper-Catalyzed Perfluoroalkylthiolation of Alkynes with Perfluoroalkanesulfenamides
A. Tlili, S. Alazet, Q. Glenadel, T. Billard 
Chem. Eur. J. 2016, 22, 10230-10234.(link)
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Agonist and antagonist bind differently to 5-HT1A receptors during Alzheimer’s disease: A post-mortem study with PET radiopharmaceuticals
B. Vidal, J. Sebti, M. Verdurand, S. Fieux, T. Billard, N. Streichenberger, C. Troakes, A. Newman-Tancredi, L. Zimmer
Neuropharmacology 2016, 109, 88-95.(link)


Metal-Free Direct Dehydroxytri­fluoromethylthiolation of Alcohols via the Umpolung Reactivity of Trifluoromethanesulfenamides
Q. Glenadel, A. Tlili, T. Billard
Eur. J. Org. Chem. 2016, 1955-1957.(link)


Direct Perfluoroalkylthiolation of Few Chalcogenols
Q. Glenadel, T. Billard
Chin. J. Chem . 2016, 34, 455-458 (Special issue, on invitation). (link)


Multigram Scale Syntheses of First and Second Generation of Trifluoromethanesulfenamide Reagents
Q. Glenadel, S. Alazet, F. Baert, T. Billard
Org. Process Res. Dev. 2016, 20, 960-964.(link)


Trifluoromethanesulfenamides: new reagents for direct S-CF3 bond formation
T. Billard
Chim. Oggi - Chem. Today 2016, 34, 18-21 (on invitation). (link)


Copper-Catalyzed Trifluoromethylation of Hydrazones Leading to the Formation of Quaternary α-Trifluoromethyl Diazenes.A. Prieto, D. Bouyssi and N. Monteiro. Asian J. Org. Chem. 2016; DOI: 10.1002/ajoc.201600160 (link)


C-H Difluoroalkylation of Aldehyde Hydrazones with Functionalized Difluoromethyl Bromides under Copper Catalysis. A. Prieto, R. Melot, D. Bouyssi, N. Monteiro. ACS Catalysis 20166, 1093


“Grignard reagents and Nickel” F. Fache, B. Pelotier, O. Piva in “Grignard Reagents and Transition Metal catalysts”; Ed J. Cossy, De Gruyter Ed., 2016, pp.61-113.(link)


Palladium-Catalyzed C(sp2) -H Alkylation of Aldehyde-Derived Hydrazones with Functionalized Difluoromethyl Bromides. A. Prieto, R. Melot, D. Bouyssi, N. Monteiro. Angew. Chem. Int. Ed. 201655, 1885.


Electrophilic Trifluoromethylation of Carbonyl Compounds and their Nitrogen Derivatives under Copper Catalysis. A. Prieto, O. Baudoin, D. Bouyssi, N. Monteiro, Chem. Commun., 2016, 52, 869.


Direct Electrophilic (Benzenesulfonyl)Difluoromethylthiolation with a Shelf-Stable Reagent. E. Ismalaj, D. Le Bars, T. Billard Angew. Chem. Int. Ed. 2016, 55, 4790-4793. (link)


Metal-Free Direct Nucleophilic Perfluoroalkylthiolation with Perfluoroalkanesulfenamides. Q. Glenadel, M. Bordy, S. Alazet, A. Tlili, T. Billard Asian J. Org. Chem. 2016, 5, 428-433. (link)


First and second generation of trifluoromethanesulfenamide reagent: A trifluoromethylthiolating comparison. Q. Glenadel, S. Alazet, T. Billard J. Fluorine Chem. 2015, 179, 89-95. (link)


Direct [11C]Methylation of Amines from [11C]CO2 for the Synthesis of PET Radiotracers. F. Liger, T. Eijsbouts, F. Cadarossanesaib, C. Tourvieille, D. Le Bars, T. Billard Eur. J. Org. Chem. 2015, 6434-6438. (link)


Mild and Soft Catalyzed Trifluoromethylthiolation of Boronic Acids: The Crucial Role of Water. Q. Glenadel, S. Alazet, A. Tlili, T. Billard Chem. Eur. J. 2015, 21, 14694-14698. (link)


TEMPO-Catalyzed Oxidative Amidation of Alcohols via Hexafluoroisopropyl Esters. J.-M. Vatèle Synlett 2015, 2280-2284.


Acid-Catalyzed Synthesis of α-Trifluoromethylthiolated Carbonyl Compounds. Alazet, S.; Ismalaj, E.; Glenadel, Q.; Le Bars, D.; Billard, T. Eur. J. Org. Chem. 2015, 4607-4610. (link)


Le fluor en chimie organique : une montée en puissance (Fluorine in organic chemistry: gaining momentum). T. Billard, E. Magnier, J.-P. Vors Actualité Chimique 2015, 393-394, 56-61. (link)


Selective trifluoromethylthiolation of heteroaromatic sp2 C–H bonds with the 2nd generation of trifluoromethanesulfenamide reagent. S. Alazet, L. Zimmer, T. Billard J. Fluorine Chem. 2015, 171, 78-81. (link)


Preclinical evaluation of [18F]2FNQ1P as the first fluorinated serotonin 5-HT6 radioligand for PET imaging. G. Becker, J. Colomb, V. Sgambato-Faure, L. Tremblay, T. Billard, L. Zimmer Eur. J. Nucl. Med. Mol. Imaging 2015, 42, 495-502. (link)


Electrophilic Aromatic Trifluoromethylthiolation with the Second Generation of Trifluoromethanesulfenamide. Alazet, S.; Billard, T. Synlett 2015, 26, 76-78. (link)


Total synthesis of (+)-Guaymasol. S. Feuillastre, O. Piva Synlett 2014, 2883-2886. (link)


TEMPO/NBu4Br-Catalyzed Selective Alcohol Oxidation with Periodic Acid. Mariam Attoui, Jean-Michel Vatèle Synlett 2014, 2923-2927. (link)


Binding of the PET radiotracer [18F]BF227 does not reflect the presence of alpha-synuclein aggregates in transgenic mice. E. Levigoureux, S. Lancelot, C. Bouillot, F. Chauveau, M. Verdurand, J. Verchere, T. Billard, T. Baron, L. Zimmer Curr. Alzheimer Res. 2014, 11, 955-960. (link)


(Re)Investigation of the reactivity of uranium hexafluoride toward several organic functions at room temperature. O. Roy, B. Marquet, J.-P. Alric, A. Jourdan, B. Morel, B. R. Langlois, T. Billard J. Fluorine Chem. 2014, 167, 74-78. (link)


A Postmortem Study to Compare Agonist and Antagonist 5-HT1A Receptor-binding Sites in Alzheimer's Disease. G. Becker, N. Streichenberger, T. Billard, A. Newman-Tancredi, L. Zimmer CNS Neurosci. Ther. 2014, 20, 930-934. (link)


Multigram Laboratory Scale Synthesis of α-Trifluoromethoxy Carbonyl Compounds. Barbion, J.; Pazenok, S.; Vors, J.-P.; Langlois, B. R.; Billard, T. Org. Process Res. Dev. 2014, 18, 1037-1040. (link)


One-pot oxidative conversion of alcohols into nitriles by using a TEMPO/PhI(OAc)2/NH4OAc system. J.-M. Vatèle. Synlett 2014, 25, 1275-1278. (link)


Electrophilic Trifluoromethylthiolation of Carbonyl Compounds. Alazet, S.; Zimmer, L.; Billard, T. Chem. Eur. J. 2014, 20, 8589-8593. (link)


Molecular imaging of the serotonin 5-HT7 receptors: from autoradiography to positron emission tomography. Zimmer, L.; Billard, T. Rev. Neurosci. 2014, 25, 357-365. (link)


Syntheses, Radiolabelings, and in Vitro Evaluations of Fluorinated PET Radioligands of 5-HT6 Serotoninergic Receptors. Colomb, J.; Becker, G.; Fieux, S.; Zimmer, L.; Billard, T. J. Med. Chem. 2014, 57, 3884-3890. (link)


Synthesis of seven-membered ring ethers and lactones. Piva, O. in "Topics in Heterocyclic Chemistry II » - Vol. 35. Maes, BUW; Cossy, J.; Polanc, S. Eds.; Springer: Heidelberg, 2014, p. 283-321.


Application of Prins Cyclization to the total synthesis of (+)-decytospolides A and B. Clarisse, D.; Fache, F. Tetrahedron Lett. 2014, 55, 2221-2222. (link)


Direct Trifluoromethylthiolation Reactions: The “Renaissance” of an Old Concept. F. Toulgoat, S. Alazet, T. Billard Eur. J. Org. Chem. 2014, 2415-2428. (link).


Synthesis and pharmacological evaluation of a new series of radiolabeled ligands for 5-HT7 receptor PET neuroimaging. Colomb, J.; Becker, G.; Forcellini, E.; Meyer, S.; Buisson, L.; Zimmer, L.; Billard, T. Nucl. Med. Biol. 2014, 41, 330-337. (link)


Stereoselective Access to Trisubstituted Cyclopentanols from Chiral Unsaturated Oxo Esters by Ketyl Radical Cyclization. S. Feuillastre, B. Pelotier, O. Piva Eur. J. Org. Chem. 2014, 1753-1759. (link)


Regioselective Oxidative Cleavage of Benzylidene Acetals of Glycopyranosides with Periodic Acid Catalyzed by Tetrabutylammonium Bromide. Jean-Michel Vatèle Synlett 2014, 25, 115-119. (link)


PET Radiotracers for Molecular Imaging of Serotonin 5-HT1A Receptors. Billard, T.; Le Bars, D.; Zimmer, L. Curr. Med. Chem. 2014, 21, 70-81. (link)


Direct electrophilic N-trifluoromethylthiolation of amines with trifluoromethanesulfenamide. Alazet, S.; Ollivier, K.; Billard, T. Beilstein J. Org. Chem. 2013, 9, 2354-2357. (link)


Sequential oxidation-Prins reaction processes induced by the same iron salt : Direct access to 2-aryl-4-chloro-tetrahydropyrans from benzyl alcohols. F. Fache, M. Muselli, O. Piva. Synlett 2013, 24, 1781-1784. (link)


Base-Catalyzed Electrophilic Trifluoromethylthiolation of Terminal Alkynes. Alazet, S.; Zimmer, L.; Billard, T. Angew. Chem. Int. Ed. 2013, 52, 10814-10817. (link)


Merging cross-metathesis and radical cyclization : A straightforward access to 4-substituted benzosultams. S. Feuillastre, B. Pelotier, O. Piva. Synthesis 2013, 45, 810-816. (link)


Solvent-free, metal-free, Aza-Prins cyclization : Unprecedented access to δ-sultams. D. Clarisse, B. Pelotier, F. Fache. Chem. Eur. J. 2013, 19, 857-860. (link)


Synthesis of trifluoromethylated 1,5-benzoheteroazepines. Carole Christophe, Bernard R. Langlois, Thierry Billard. J. Fluorine Chem. 2013, 155, 118 – 123. (link)


Formation of C-SCF3 Bonds through Direct Trifluoromethylthiolation. Anis Tlili and Thierry Billard. Angew. Chem. Int. Ed. 2013, 52, 6818 – 6819. (link)


Unusual reactivities of acridine derivatives in catalytic hydrogenation. A combined experimental and theoretical study. Mignon, P.; Tiano, M.; Belmont, P.; Favre-Réguillon, A.; Chermette, H.; Fache, F. J. Mol. Catal. A: Chemical, 2013, 371, 63-69. (link)


Synthetic Studies on the Nhatrangins: Stereoselective Access to an Advanced Aldehyde Intermediate. Ludovic Raffier and Olivier Piva. Eur. J. Org. Chem. 2013, 1124–1131. (link)


Palladium-catalyzed desulfitative arylation of 3-haloquinolines with arylsulfinates. Julie Colomb, Thierry Billard. Tetrahedron Letters 2013, 54, 1471–1474. (link)


Asymmetric synthesis of andavadoic acid via base-catalyzed 5-exo-tet cyclization of a β-hydroperoxy epoxide. Bogdan Barnych, Bernard Fenet, Jean-Michel Vatèle. Tetrahedron, 2013, 69, 334-340. (link)


Acetogenin (Polypropionate) Derived Auxillaries: Hydroxyacids. O. Piva. In: Carreira E.M. and Yamamoto H. (eds.) Comprehensive Chirality, 2012, Amsterdam: Elsevier, Volume 3, pp. 202-213.


Acetogenin (Polypropionate) Derived Auxillaries: Hydroxyacid Derivatives. O. Piva. In: Carreira E.M. and Yamamoto H. (eds.) Comprehensive Chirality, 2012, Amsterdam: Elsevier, Volume 3, pp. 214-222.


Merging metathesis and organic, organocatalysis with photochemistry. O. Piva. European Photochemistry Newsletter, Dec. 2012, 62-64


Plakortolide Stereochemistry Revisited: The Checkered History of Plakortolides E and I. Ken W. L. Yong, Bogdan Barnych, James J. De Voss, Jean-Michel Vatèle, and Mary J. Garson. J. Nat. Prod. 2012, 75, 1792−1797.


Electrophilic Trifluoromethanesulfanylation of Organometallic Species with Trifluoromethane-sulfanamides. Baert, F.; Colomb, J.; Billard, T. Angew. Chem. Int. Ed. 2012, 51, 10382-10385. (link)


Hexafluoroisopropanol: a powerful solvent for the hydrogenation of indole derivatives. Selective access to tetrahydroindoles or cis-fused octahydroindoles. Damien Clarisse, Bernard Fenet, Fabienne Fache. Org. Biomol. Chem. 2012, 10, 6587-6594.


Application of a Cross-Metathesis and Intramolecular Aza-Diels–Alder Sequence to the Synthesis of trans-2,3-Disubstituted Tetrahydroquinolines. Sophie Feuillastre, Vincent Pellet, Olivier Piva. Synthesis 2012, 2431-2435.


Total Synthesis of Bistramide A and Its 36(Z) Isomers: Differential Effect on Cell Division, Differentiation, and Apoptosis. Loc Tomas, Gustav Boije af Gennäs, Marie Aude Hiebel, Peter Hampson, David Gueyrard, Béatrice Pelotier, Jari Yli-Kauhaluoma, Olivier Piva, Janet M. Lord, Peter G. Goekjian. Chem. Eur. J. 2012, 18, 7452 – 7466.


Radiosynthesis and Preclinical Evaluation of 18F-F13714 as a Fluorinated 5-HT1A Receptor Agonist Radioligand for PET Neuroimaging. Laëtitia Lemoine, Guillaume Becker, Bernard Vacher, Thierry Billard, Sophie Lancelot, Adrian Newman-Tancredi, and Luc Zimmer. J. Nucl. Med. 2012, 53, 969-976. (link)


Exploratory studies toward the synthesis of the peroxylactone unit of plakortolides. Bogdan Barnych, Jean-Michel Vatèle. Tetrahedron, 2012, 68, 3717-3724.


Electrophilic trifluoromethanesulfanylation of indole derivatives. Aurélien Ferry, Thierry Billard, Eric Bacqué, Bernard R. Langlois. J. Fluorine Chem., 2012, 134, 160-163. (link)


Total Synthesis of seco-Plakortolide E and (−)-ent-Plakortolide I: Absolute Configurational Revision of Natural Plakortolide I. Bogdan Barnych, Jean-Michel Vatèle. Org. Lett., 2012, 14, 564–567.


Easy access to 2-alkyl and 2-arylthiazolines using microwave irradiation and heteropolyacid catalysis. F. Fache, F. Cros, O. Piva, F. Lefebvre. Synth. Commun 2012, 42, 2098-2109.


Green chemistry: solvent- and metal-free Prins cyclization. Application to sequential reactions. Damien Clarisse, Béatrice Pelotier, Olivier Piva and Fabienne Fache. Chem. Commun. 2012, 48, 157-159.


Desymmetrization of Hepta-1,6-dien-4-ol by Prins Reaction and Subsequent. Cross-Metathesis: Access to Diospongine A Homologues. L. Raffier, F. Izquierdo, O. Piva. Synthesis, 2011, 4037-4044.


Comparison of 4 Radiolabeled Antagonists for Serotonin 5-HT7 Receptor Neuroimaging: Toward the First PET Radiotracer. Laetitia Lemoine, Julien Andries, Didier Le Bars, Thierry Billard, Luc Zimmer. J. Nucl. Med. 2011, 52, 1811-1818. (link)


La métathèse: une ronde d'atomes. O. Piva. Pour la Science Dossier N°73: Les Océans et la chimie durable. Oct.-Déc. 2011, 64-68.


Towards the Synthesis of 4,19-diol Derivative of (-)-Mycothiazole: Synthesis of a Potential Key Intermediate. F. Batt, F. Fache. Eur. J. Org. Chem. 2011, 6039-6055.


(1S,2R,4R)-2-allyl-1,7,7-trimethylbicyclo[2.2.1]heptan-2-ol. L. Raffier, O. Piva. Electronic encyclopedia of reagents for organic synthesis - Wiley 2011.


One-Pot Bi(OTf)3-Catalyzed Oxidative Deprotection of tert-Butyldimethyl Silyl Ethers with TEMPO and Co-Oxidants . Bogdan Barnych, Jean-Michel Vatèle. Synlett 2011, 2048-2052.


1,4-Additions of electron-rich heterocycles onto β-perfluoroalkyl enones. Julia Leuger, Gaelle Blond, Thierry Billard, Günter Haufe, Bernard R. Langlois. J. Fluorine Chem. 2011, 132, 799-803. (link)


Synthetic Studies toward the Bicyclic Peroxylactone Core of Plakortolides. Bogdan Barnych, Jean-Michel Vatèle. Synlett 2011, 1912-1916.


Synthesis and Biological Evaluation of Potential 5-HT7 Receptor PET Radiotracers. Julien Andriès, Laetitia Lemoine, Didier Le Bars, Luc Zimmer, Thierry Billard. Eur. J. Med. Chem. 2011, 46, 3455-2461. (link)


Application of the diastereoselective photodeconjugation of α,β-unsaturated esters to the synthesis of Gymnastatin. H. L. Raffier, O. Piva. Beilstein J. Org. Chem. 2011, 7, 151–155.


Synthesis of 6-(1,2,3-triazoloalkyl)-a-pyrones by a cascade RCM/CM and click chemistry sequence. F. Cros, J. Ruiz, B. Pelotier, O. Piva .Synlett 2010, 2621-2624


Bromotrichloromethane. F. Cros. Synlett 2010, 2204-2205


Stereoselective synthesis of the C1-C13 fragment of bistramide A. M. A. Hiebel, B. Pelotier, O. Piva. Tetrahedron Lett. 2010, 51, 5091-5093.


Synthesis of β-Trifluoromethylated Δ1-Pyrrolines. Olivier Marrec, Carole Christophe, Thierry Billard, Bernard Langlois, Jean-Pierre Vors, Sergii Pazenok. Adv. Synth. Catal. 2010, 352, 2825 – 2830. (link)


A New and Direct Trifluoromethoxylation of Aliphatic Substrates with 2,4-Dinitro(trifluoromethoxy)benzene. Olivier Marrec, Thierry Billard, Jean-Pierre Vors, Sergii Pazenok, Bernard R. Langlois. Adv. Synth. Catal. 2010, 352, 2831 – 2837. (link)


Lewis acid-catalyzed oxidative rearrangement of tertiary allylic alcohols mediated by TEMPO. J.-M. Vatèle. Tetrahedron 2010, 66, 904-912.


Looking for a 5-HT7 radiotracer for positron emission tomography. Julien Andriès, Laëtitia Lemoine, Alice Mouchel-Blaisot, Sandrine Tang, Mathieu Verdurand, Didier Le Bars, Luc Zimmer, Thierry Billard. Bioorg. Med. Chem. Lett. 2010, 20, 3730-3733. (link)


Regioselective Tandem Ring-Closing/Cross-Metathesis of 1,5-hexadien-3-ol derivatives: Application to a Total Synthesis of Rugulactone F. Cros, B. Pelotier, O. Piva Eur. J. Org. Chem. 2010, 5063-5070.


Stereocontrolled Synthesis of a Highly Functionalized Core Structure of the Aurisides by Ring-Closing Metathesis E. Bourcet, F. Fache, O. Piva Eur. J. Org. Chem. 2010, 4075-4087 .


Vers une chimie moléculaire verte. J. M. Campagne, F. Agbossou, T. Ayad, O. Baudoin, G. Buono, I. Chataignier, C. Crévisy, I. Dez, M. Donnard, F. Fache, C. Feasson, A-C. Gaumont, L. Giordano, P. Heseman, F. Marsais, M. Mauduit, V. Michelet, A. Mortreux, P. Phansavath, O. Piva, J.P. Roblin, J. Rouden, M. Taillefer, P. Y. Toullec, T. Tschmaber, V. Vidal Actualité Chimique 2010, 338-339, 14-27.


Synthesis of the core structure of the aurisides. E. Bourcet, F. Fache, O. Piva Tetrahedron 2010, 66, 1319-1326.


Microwave-assisted cross-metathesis of unsaturated thiocyanates: Application to the synthesis of thiocyanatins A and B and analogues. F. Cros, B. Pelotier, O. Piva Synthesis 2010, 233-238.


A deeper insight into direct trifluoromethoxylation with trifluoromethyl triflate. Olivier Marrec, Thierry Billard, Jean-Pierre Vors, Sergii Pazenok, Bernard R. Langlois. J. Fluorine Chem. 2010, 131, 200-207. (link)