Metathesis in sequential procedures

Metathesis reactions have been combined with different procedures (sequential or tandem) to achieve a rapid access to various heterocycles

Image1

 

Organometallic catalysis in organic synthesis

Copper-Catalyzed Trifluoromethylation of Hydrazones Leading to the Formation of Quaternary α-Trifluoromethyl Diazenes. A. Prieto, D. Bouyssi and N. Monteiro. Asian J. Org. Chem. 2016; DOI: 10.1002/ajoc.201600160

Image2

 

C-H Difluoroalkylation of Aldehyde Hydrazones with Functionalized Difluoromethyl Bromides under Copper Catalysis. A. Prieto, R. Melot, D. Bouyssi, N. Monteiro. ACS Catalysis 2016, 6, 1093.

Image3

 

Palladium-Catalyzed C(sp2) -H Alkylation of Aldehyde-Derived Hydrazones with Functionalized Difluoromethyl Bromides. A. Prieto, R. Melot, D. Bouyssi, N. Monteiro. Angew. Chem. Int. Ed. 2016, 55, 1885.

Image4

 

Electrophilic Trifluoromethylation of Carbonyl Compounds and their Nitrogen Derivatives under Copper Catalysis. A. Prieto, O. Baudoin, D. Bouyssi, N. Monteiro, Chem. Commun., 2016, 52, 869.

Image5

 

Copper-Catalyzed Trifluoromethylation of Aliphatic N-Arylhydrazones: A Concise Synthetic Entry to 2-Trifluoromethylindoles from Simple Aldehydes. A. Prieto, M. Landart, O. Baudoin, N. Monteiro, D. Bouyssi, Adv. Synth. Catal., 2015, 357, 2939.

Image6

 

Copper-catalyzed trifluoromethylation of conjugated hydrazones. A. Prieto, E. Jeamet, N. Monteiro, D. Bouyssi, O. Baudoin, Org. Lett. 2014, 16, 4770 / Highlighted in Synfacts, 2014 by M. Lautens.

Image7

 

Copper-catalyzed trifluoromethylation of N,N-dialkylhydrazones. E. Pair, N. Monteiro, D. Bouyssi, O. Baudoin, Angew. Chem., Int. Ed. 2013, 52, 5346.

Image8