Organic Synthetic MethodSynthesis and Methodology applied to biomolecules
Total synthesis of a target molecule with most often interesting or even unique biological properties represents a challenge to demonstrate the applicability of a pre-established methodologies or in contrast the need to develop new processes. In the two cases, it is a unique opportunity for learning and mastering organic chemistry. The research carried out in the unit is focused on many targets (alkaloids, terpenes, heterocycles, polyketides ...) involving organometallic couplings, organo- and biocatalyzed reactions, multicomponent reactions, electro- and photochemical processes but also the valorization of natural products as highly functionnalized scaffolds.
Publications Find the most recent scientific contributions
The Use of 5-Hydroxymethylfurfural (5-HMF) in Multi- Component Hantzsch Dihydropyridine Synthesis
Jingjing Jiang, Yves Queneau, Florence Popowycz
ChemSusChem 2024, e202301782
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3D MODEL of an anatomically inert human hand: feasibility study
Lucchino, N.; Pialat, J-B.; Marquette, C.; Courtial, E.; Erhard, L.; Voulliaume, D.; Mojallal, A.; Gazarian, A.
Hand Surgery and Rehabilitation 101709
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Hydride-free reduction of propargyl electrophiles: A nickel-catalyzed photoredox strategy for allene synthesis
Hu, Tingjun; Fagué, Vincent; Bouyssi, Didier; Monteiro, Nuno; Amgoune, Abderrahmane
Green Chem, 2024, Accepted Manuscript
Read the whole publicationStereodivergent, kinetically controlled isomerization of terminal alkenes via nickel catalysis.
Rubel, Camille Z.; Ravn, Anne K.; Ho, Hang Chi; Yang, Shenghua; Li, Zi-Qi; Engle, Keary Mark; Vantourout, Julien C.
Angew. Chem. Int. Ed. 2024, e202320081
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Unlocking the Power of Acyl Fluorides: A Comprehensive Guide to Synthesis and Properties
Clémence Bonnefoy, Adrien Gallego, Clément Delobel, Betty Raynal, Maxime Decourt, Emmanuel Chefdeville, Gilles Hanquet, Armen Panossian, Frédéric R. Leroux, Fabien Toulgoat, Thierry Billard