Chemistry at the interface with Biology and MedicineChimie médicinale
Several teams are developing Medicinal Chemistry projects, i.e. the design and optimization of molecular structures (small molecules or more elaborated scaffolds), with therapeutic and chemobiological applications. Several strategies could be developped and use advantage of key informations from structure-activity relationship studies, screening campaigns, the diversity of products of natural origin, and measurements of ligand/protein interactions using different techniques, such as X-ray diffraction, Nuclear Magnetic Resonance, Surface Plasmon Resonance, Isothermal Calorimetric Titration or Mass Spectrometry.
Publications Find the most recent scientific contributions
The Use of 5-Hydroxymethylfurfural (5-HMF) in Multi- Component Hantzsch Dihydropyridine Synthesis
Jingjing Jiang, Yves Queneau, Florence Popowycz
ChemSusChem 2024, e202301782
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3D MODEL of an anatomically inert human hand: feasibility study
Lucchino, N.; Pialat, J-B.; Marquette, C.; Courtial, E.; Erhard, L.; Voulliaume, D.; Mojallal, A.; Gazarian, A.
Hand Surgery and Rehabilitation 101709
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Hydride-free reduction of propargyl electrophiles: A nickel-catalyzed photoredox strategy for allene synthesis
Hu, Tingjun; Fagué, Vincent; Bouyssi, Didier; Monteiro, Nuno; Amgoune, Abderrahmane
Green Chem, 2024, Accepted Manuscript
Read the whole publicationStereodivergent, kinetically controlled isomerization of terminal alkenes via nickel catalysis.
Rubel, Camille Z.; Ravn, Anne K.; Ho, Hang Chi; Yang, Shenghua; Li, Zi-Qi; Engle, Keary Mark; Vantourout, Julien C.
Angew. Chem. Int. Ed. 2024, e202320081
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Unlocking the Power of Acyl Fluorides: A Comprehensive Guide to Synthesis and Properties
Clémence Bonnefoy, Adrien Gallego, Clément Delobel, Betty Raynal, Maxime Decourt, Emmanuel Chefdeville, Gilles Hanquet, Armen Panossian, Frédéric R. Leroux, Fabien Toulgoat, Thierry Billard